CoNDA Pilot Projects
Dr. Jieqiong Wang | UNMC
The Association between Brain Age and DNA Methylation Age at the Global and the Local Level
Led by Dr. Jieqiong Wang, PhD
Dr. Wang is an Assistant Professor in the Department of Neurological Sciences at UNMC. Her Pilot Project seeks to investigate her hypothesis that the brain age is associated with DNAm age, using multiple models including diffusion tensor imaging (DTI), resting state functional MRI (rs-fMRI), and machine learning (ML) models for voxel-wise brain age estimation. In collaboration with Dr. Howard Fox's lab, Dr. Wang will integrate brain age (obtained through conventional ML or deep learning) and DNAm age to unravel the complex interdependence mechanisms underlying aging processes, and provide insights into strategies for preventing accelerated aging.