Xie Lab
The research interests for the Xie lab centers on the synthesis, surface modification and self-assembly of materials at nanometer scale to address problems in the field of tissue engineering, regenerative medicine and drug/gene delivery. Our research programs are built upon interdisciplinary subjects including materials science, engineering, biology and medicine. We develop novel, smart biomaterials with well-controlled composition, structure and functional properties. We employ analytical tools in materials science, biology and medicine to characterize these biomaterials as either scaffolds or drug/gene carriers. Specifically, we are interested in use of nano-structured materials together with signaling molecules to regulate cell/stem cell behaviors for regenerating various types of tissues. We are also interested in developing nanofibrous materials for topical delivery of therapeutic agents (e.g., antimicrobial peptides, chemotherapeutic drugs, cytokines and growth factors).
Jingwei Xie, PhD, Principal Investigator
Dr. Xie received his bachelor's and master's degrees from Nanjing University of Technology, China, and his doctoral degree under professor Chi-Hwa Wang from the National University of Singapore in 2007. He worked as a postdoctoral fellow in the Xia group, under professor Younan Xia (relocated to Georgia Institute of Technology) at Washington University in St. Louis. He is currently a professor in the Department of Surgery, Division of Transplant Surgery and Holland Regenerative Medicine Program at University of Nebraska Medical Center. He is also an adjunct faculty in the Department of Mechanical & Materials Engineering at the University of Nebraska-Lincoln.
Dr. Xie has won a number of awards, including the UNMC New Investigator Award in 2015, Most Promising Invention Award in 2017, Licensed Technology Award in 2017 and 2018, Dr. Harold & Beverly Maurer Scientific Achievement Award, The Nebraska Coalition for Lifesaving Cures in 2019, WashU patent award in 2019 and 2020, and UNMC Distinguished Scientist Award in 2020. His research interests include biomaterials, drug delivery, nanomedicine, tissue engineering, regenerative medicine, wound infection and healing, and hemostasis.
Lab Members
Dr. Sharma received her B.Tech in biotechnology from Jawaharlal Nehru Technological University, Hyderabad, India. She was awarded PhD from the Department of Pathology and Microbiology at University of Nebraska at Medical Center in the field of prostate cancer bone metastasis under the supervision of Dr. Kaustubh Datta. Her research interests are 3D in-vitro disease modeling and bone tissue engineering.
Dr. Andrabi is a postdoctoral research fellow in the Xie Lab at the University of Nebraska Medical Center. Before joining UNMC, during his tenure as a research associate and graduate student at the Indian Institute of Technology Kanpur, India, he worked on the design, development and characterization of functionalized biomaterials as multifaceted 3D/2D scaffolds and nano/micro-carriers for drug delivery and tissue engineering applications. His research interest focuses on developing intelligent and multifunctional biomaterials, microneedles and nanocomposites for improved biomedical and therapeutic applications.
Dr. Tran was born in Ho Chi Minh City, Vietnam. He earned his master's degree and PhD in material science from Swinburne University of Technology, Australia, in 2017 and 2021, respectively. In March 2022, he joined Dr. Xie’s lab as a research fellow. His research interests focus on nano-structured materials for biomedical applications and drug delivery systems.
Dr. Wang, originally from Shandong Province, China, earned his PhD in chemistry from Tsinghua University in 2022. In September 2023, he embarked on his postdoctoral journey as a research fellow at Xie Lab. Dr. Wang's academic pursuits center around 3D printing, hydrogels, tissue adhesives and regenerative medicine.
Dr. Yan was born in Shanxi Province, China. She obtained her PhD degree from the Innovation Center for Textile Science and Technology at Donghua University in 2023. She joined Xie Lab as a postdoctoral research fellow in January 2024. Her research interests focus on hierarchical structure design and construction for piezoelectric biomaterials.
Dr. Ma received his PhD degree in biology from University of Chinese Academy of Sciences in 2021. His research interests are biomaterials, peripheral nerve injury, and regenerative medicine.
Shatil, originally from Bangladesh, holds bachelor's and master's degrees in pharmaceutical sciences from the University of Development Alternative, Bangladesh, and a ME of Chemical and Biological Engineering from Korea National University, South Korea. Shatil is a PhD candidate at the University of Nebraska Medical Center. Shatil's research interests focus on hemostats, wound healing, biomaterials design and engineering, medical device technology, bacterial biofilm eradication, and drug delivery.
Busquets was born in Mayaguez, Puerto Rico. He graduated from Antillean Adventist University where he obtained a BS in biomedical sciences. In January 2024 he joined the Eppley Institute for Research in Cancer and Allied Diseases as a cancer research doctoral student. He is interested in tissue engineering biomaterials, drug delivery, cancer, surgery, and regenerative medicine.
Patents and Patent Applications
- Xie J, Nanofiber structures and methods of synthesis and modification, US provisional patent, No. 62560314, 2017.
- Xie J, Carlson MA, Expanded Nanofiber Scaffolds for Tissue Engineering, US provisional patent, No. 62517310, 2017.
- Xie J, Wang G, Nanofiber dressings for controlled delivery of peptides, US provisional patent No. 65/510,923, 2017.
- Xie J, Chen S, Carlson MA, Electrospun nanofiber-based hemostatic materials, US provisional patent No. 62400700, 2016.
- Xie J, Chen S, Baxter T, Ring and tubular devices for tailoring drug release and delivery, US provisional patent No. 62365023, 2016.
- Xie J, Jiang J, Nanofiber structures and methods of synthesis and use thereof. US provisional patent No. 62056899, 2014. PCT /US2015/052858. WO2016053988 A1.
- Xie J, Ma B, Nanofiber-based scaffolds and methods for repair skin injury in a large wound area. U.S. Patent Application Serial No. 61/666,260.
- Xie J, Nanofiber scaffolds and methods for repairing damaged cardiac tissue. U.S. Patent Application Serial No. 61/586,866, issued in Jan, 2017.
- Leuthardt E, Moran D, Holtzman D, Bayly P, Brody D, Dacey RG, Fok S, Garrison J, Genin G, Lusis E, Pappu R, Xie J, Zipfel G, Altering protein concentrations in cerebrospinal fluid and/or brain interstitial fluid. WIPO Patent Application WO/2012/145428. International Application No.: PCT/US2012/034120.
- MacEwan MR, Xie J, Ray WZ, Xia Y, Nanofiber dural substitute and nanofiber dural patch. U.S. Patent Application Serial No. 61/35572. MacEwan MR, Xie J, Ray WZ, Xia Y, Biomedical patches with aligned fibers. WO 2011/159889 A2, Pub. Date: Dec. 22, 2012. (This patent has been licensed by a company Acera Surgical Inc. St. Louis, the product was approved by FDA for pre-market in March 2016.)
- Thomopoulos S, Sakiyama-Elbert S, Silva M, Gelberman R, Xia Y, Schwartz A, Xie J, Nanofiber scaffolds for delivery of heparin binding growth factors. S. Patent Pub. No.: US 2013/0004541 A1, Pub. Date: Jan. 3, 2013.
- A pilot grant entitled “Novel 3D nanofiber aerogels for healing large cranial bone defects” from UNMC CDDN NIH COBRE. June. 2017.
- A NE LB606 stem cell project grant entitled “3D nanofiber scaffolds homing stem cells for cartilage regeneration”. Oct. 2017.
- A 2017 Great Plains IDeA-CTR Pilot grant entitled “Injectable and Expandable Nanofiber Foams for Treating Noncompressible Hemorrhage”. June 2017.
- A National Institute of Health R01 grant entitled “Nanofiber-based delivery of combined immune-modulating compounds to minimize infection and enhance wound healing”. May 2017.
- A pilot grant entitled “Small Intestine Regeneration” from Regenerative Medicine Program. April 2017.
- A pilot grant entitled “Nanofiber Scaffolds for Cartilage Regeneration” from Regenerative Medicine Program. Nov. 2016.
- A pilot grant entitled “Nanofiber Scaffolds for Periodontal Bone Regeneration” from Regenerative Medicine Program. July 2016.
- Mark A. Carlson, MD, UNMC
- Guangshun Wang, PhD, UNMC
- Shannon L. Wong, MD, UNMC
- Kai Yang, MD, UNMC
- Ronald R. Hollins, MD, UNMC
- Matthew J. Teusink, MD, UNMC
- Adrian F. Gombart, PhD, Oregon State University
- Indra Arup, PhD, Oregon State University
- Yu Shrike Zhang, PhD, Harvard University
- Zheng Yan, PhD, University of Missouri Columbia
- Wuqiang Zhu, MD, PhD, Mayo Clinic
- Xinping Zhang, MD, PhD, University of Rochester
Jingwei Xie, PhD
Principal Investigator
Research Scientist and Professor
Phone: 402-559-9442
Email: jingwei.xie@unmc.edu