Category: Published Research
Science – Obesity, characterized by chronic low-grade inflammation of the adipose tissue, is associated with adverse coronavirus disease 2019 (COVID-19) outcomes, yet the underlying mechanism is unknown. To explore whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection of adipose tissue contributes to pathogenesis, we evaluated COVID-19 autopsy cases and deeply profiled the response of […]
Sep 25, 2022
SARS-CoV-2 Omicron and its current known unknowns: A narrative review
Pub Med – The emergence of the SARS-CoV-2 Omicron variant (B.1.1.529) has created great global distress. This variant of concern shows multiple sublineages, importantly B.1.1.529.1 (BA.1), BA.1 + R346K (BA.1.1), and B.1.1.529.2 (BA.2), each with unique properties. However, little is known about this new variant, specifically its sub-variants. A narrative review was conducted to summarise […]
Sep 24, 2022
Mixing patterns and the spread of pandemics
Nature – Integrating social mixing data into epidemic models can help policy makers better understand epidemic spread. However, empirical mixing data might not be immediately available in most populations. In a recent work, a network model methodology is proposed to construct micro-level social mixing structure when empirical data are not available.
Sep 23, 2022
Reinfections with Different SARS-CoV-2 Omicron Subvariants, France
CDC – We describe 188 patients in France who were successively infected with different SARS-CoV-2 Omicron subvariants, including BA.1, BA.2, and BA.5. Time between 2 infections was <90 days for 50 (26.6%) patients and <60 days for 28 (14.9%) patients. This finding suggests that definitions for SARS-CoV-2 reinfection require revision.
Sep 23, 2022
Pulmonary Dysfunction after Pediatric COVID-19
Radiology – Long COVID occurs in lower frequency in children and adolescents than in adults. Morphologic and free-breathing phase-resolved functional low-field MRI may identify persistent pulmonary manifestations after SARS-CoV-2 infection.
Sep 23, 2022
Circulating anti-nuclear autoantibodies in COVID-19 survivors predict long-COVID symptoms
European Respiratory Journal – Autoimmunity has been reported in patients with severe COVID-19. We investigated whether antinuclear/extractable-nuclear antibodies (ANAs) were present up to a year after infection, and if they were associated with the development of clinically relevant Post-Acute Sequalae of COVID-19 (PASC) symptoms.
Sep 23, 2022
An ACE2-dependent Sarbecovirus in Russian bats is resistant to SARS-CoV-2 vaccines
PLoS Pathogens – Spillover of sarbecoviruses from animals to humans has resulted in outbreaks of severe acute respiratory syndrome SARS-CoVs and the ongoing COVID-19 pandemic. Efforts to identify the origins of SARS-CoV-1 and -2 has resulted in the discovery of numerous animal sarbecoviruses–the majority of which are only distantly related to known human pathogens and […]
Sep 23, 2022
SciTech Daily – If you’ve had COVID-19, it may still be messing with your brain. According to new research, those who have been infected with the SARS-CoV-2 virus are at increased risk of developing a range of neurological conditions in the first year after the infection. A comprehensive analysis of federal health data reveals that such complications include […]
Sep 23, 2022
Household transmission of the SARS-CoV-2 Omicron variant in Denmark
Nature – In late 2021, the Omicron SARS-CoV-2 variant overtook the previously dominant Delta variant, but the extent to which this transition was driven by immune evasion or a change in the inherent transmissibility is currently unclear. We estimate SARS-CoV-2 transmission within Danish households during December 2021. Among 26,675 households (8,568 with the Omicron VOC), […]
Sep 23, 2022
Nirmatrelvir–Ritonavir and Viral Load Rebound in Covid-19
NEJM – Cases of recurrence of clinical symptoms of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) after completion of treatment with nirmatrelvir–ritonavir have been reported by researchers1 and in a Centers for Disease Control and Prevention Health Advisory.2 The frequency and clinical implications of potential recurrence of coronavirus disease 2019 (Covid-19) are unknown.
Sep 22, 2022