Category: Published Research
SARS-CoV-2 infects adipose tissue in a fat depot- and viral lineage-dependent manner
(Nature) Visceral adiposity is a risk factor for severe COVID-19, and a link between adipose tissue infection and disease progression has been proposed. Here we demonstrate that SARS-CoV-2 infects human adipose tissue and undergoes productive infection in fat cells. However, susceptibility to infection and the cellular response depends on the anatomical origin of the cells […]
Dec 20, 2022
Data-driven identification of post-acute SARS-CoV-2 infection subphenotypes
(Nature) The post-acute sequelae of SARS-CoV-2 infection (PASC) refers to a broad spectrum of symptoms and signs that are persistent, exacerbated or newly incident in the period after acute SARS-CoV-2 infection. Most studies have examined these conditions individually without providing evidence on co-occurring conditions. In this study, we leveraged the electronic health record data of […]
Dec 20, 2022
Chemosensory deficits are best predictor of serologic response among individuals infected with SARS-CoV-2
(PLoS) Smell and taste alteration are closely linked to infection with SARS-CoV-2 and may be associated with a more indolent disease course. Serologic response rates among individuals with mild disease remains limited. We sought to identify whether chemosensory changes associated with COVID-19 were predictive of a serologic response.
Dec 16, 2022
Apparent risks of postural orthostatic tachycardia syndrome diagnoses after COVID-19 vaccination and SARS-Cov-2 Infection
(Nature Cardiovascular Research) Postural orthostatic tachycardia syndrome (POTS) was previously described after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection; however, limited data are available on the relation of POTS with Coronavirus Disease 2019 (COVID-19) vaccination. Here we show, in a cohort of 284,592 COVID-19-vaccinated individuals, using a sequence–symmetry analysis, that the odds of POTS […]
Dec 13, 2022
BA.2 and BA.5 omicron differ immunologically from both BA.1 omicron and pre-omicron variants
(Nature) Several studies have shown that SARS-CoV-2 BA.1 omicron is an immune escape variant. Meanwhile, however, omicron BA.2 and BA.5 became dominant in many countries and replaced BA.1. As both have several mutations compared to BA.1, we analyzed whether BA.2 and BA.5 show further immune escape relative to BA.1. Here, we characterized neutralization profiles against […]
Dec 13, 2022
Severe COVID-19 is associated with molecular signatures of aging in the human brain
(Nature Aging) As coronavirus disease 2019 (COVID-19) and aging are both accompanied by cognitive decline, we hypothesized that COVID-19 might lead to molecular signatures similar to aging. We performed whole-transcriptome analysis of the frontal cortex, a critical area for cognitive function, in individuals with COVID-19, age-matched and sex-matched uninfected controls, and uninfected individuals with intensive […]
Dec 12, 2022
The negative impact of COVID-19 on working memory revealed using a rapid online quiz
(PLoS) Although coronavirus disease 2019 (COVID-19) affects the respiratory system, it can also have neurological consequences leading to cognitive deficits such as memory problems. The aim of our study was to assess the impact of COVID-19 on working memory function. We developed and implemented an online anonymous survey with a working memory quiz incorporating aspects […]
Dec 6, 2022
Residual Lung Abnormalities Following COVID-19 Hospitalization: Interim Analysis of the UKILD Post-COVID Study
(American Journal of Respiratory and Critical Care Medicine) Rationale. Shared symptoms and genetic architecture between COVID-19 and lungfibrosis suggests SARS-CoV-2 infection may lead to progressive lung damage.Objectives. The UKILD Post-COVID study interim analysis was planned to estimate theprevalence of residual lung abnormalities in people hospitalized with COVID-19 based onrisk strata. Methods. The Post-HOSPitalisation COVID Study […]
Dec 5, 2022
Medical Masks Versus N95 Respirators for Preventing COVID-19 Among Health Care Workers
(Annals of Internal Medicine) Background: It is uncertain if medical masks offer similar protection against COVID-19 compared with N95 respirators. Objective: To determine whether medical masks are noninferior to N95 respirators to prevent COVID-19 in health care workers providing routine care. Design: Multicenter, randomized, noninferiority trial. (ClinicalTrials.gov: NCT04296643).
Nov 29, 2022
A multivalent nucleoside-modified mRNA vaccine against all known influenza virus subtypes
(Science) Because we cannot currently predict which subtype of the influenza virus will cause the next pandemic, researchers have made various attempts to produce a “universal” vaccine that could protect people from a wide swathe of subtypes. Although most of these efforts have focused on a limited set of antigens that are shared by many […]
Nov 29, 2022