Category: Published Research
A practical update on the management of patients with COVID–19
Royal College of Physicians – While vaccines against COVID-19 are being rolled out, an ongoing need remains for therapies to treat patients who have symptomatic COVID-19 before vaccination or in whom breakthrough infection develops. Dexamethasone and interleukin-6 inhibitors have been the mainstay of treatment for severe to critical COVID-19 requiring hospitalisation. However, in the previous […]
Sep 27, 2022
Hybrid immunity and strategies for COVID-19 vaccination
The Lancet Infectious Diseases – Since April, 2022, BA.2.12.1, BA.4, and BA.5 subvariants of the omicron (B.1.1.529) SARS-CoV-2 variant of concern have been spreading globally with increased viral fitness and transmissibility. Omicron BA.5 subvariant is currently the predominant COVID-19 threat worldwide. With the emergence of the antigenically distinct variants of concern, either natural immunity or […]
Sep 27, 2022
COVID-19 Patient Characteristics and Time to Viral Clearance: A Retrospective Observational Study in a Multiethnic Population (UAE)
Journal of Clinical Virology – The factors contributing to delayed viral clearance in COVID-19 are still unclear.•The authors investigated these factors in a study of a multiethnic population.• Advanced age, cardiovascular comorbidity, and severe COVID-19 all led to Delayed viral clearance• This early recognition enables for a detailed strategy to optimize the outcome.
Sep 27, 2022
Test predicts which COVID-19 patients will grow worse, Stanford Medicine study find
Stanford Medicine – Elevated virus levels in hospitalized COVID-19 patients’ blood predicts worsening respiratory symptoms and suggests ongoing viral replication in later disease stages, Stanford Medicine-led study says. A one-time test could predict which people hospitalized with COVID-19 are likely to worsen significantly during their stay, even if they were admitted with relatively mild symptoms, […]
Sep 26, 2022
The transcriptional regulator CtrA controls gene expression in Alphaproteobacteria phages: Evidence for a lytic deferment pathway
Frontiers in Microbiology – Pilitropic and flagellotropic phages adsorb to bacterial pili and flagella. These phages have long been used to investigate multiple aspects of bacterial physiology, such as the cell cycle control in the Caulobacterales. Targeting cellular appendages for adsorption effectively constrains the population of infectable hosts, suggesting that phages may have developed strategies […]
Sep 26, 2022
Lingering cardiac involvement in previously well people after mild COVID-19
Nature Medicine – Lingering cardiac symptoms, including exercise intolerance, tachycardia and chest pain, are increasingly recognized as post-acute COVID-19 sequelae1. In patients with a severe course of initial illness, accrued cardiac injury and pre-existing conditions readily explain cardiac symptoms. However, signs of cardiac injury such as elevated troponin levels and structural heart disease are rare […]
Sep 26, 2022
Clinical studies of detecting COVID-19 from exhaled breath with electronic nose
Nature – The COVID-19 pandemic has attracted numerous research studies because of its impact on society and the economy. The pandemic has led to progress in the development of diagnostic methods, utilizing the polymerase chain reaction (PCR) as the gold standard for coronavirus SARS-CoV-2 detection. Numerous tests can be used at home within 15 min or […]
Sep 26, 2022
Monkeypox in a Young Infant
CDC – In August 2022, the Florida Department of Health (FDOH) was notified of a suspected case of monkeypox in an infant aged <2 months who was admitted to a Florida hospital with a rash and cellulitis. This case report highlights findings from the related epidemiologic investigation and describes the public health actions taken. This […]
Sep 26, 2022
Neurologic Complications of Smallpox and Monkeypox
JAMA Neurology – Orthopox viruses include smallpox virus, a once feared but now eradicated virus, as well as monkeypox virus. Monkeypox is an emerging virus initially isolated in 1958, previously unrecognized outside sub-Saharan Africa until a worldwide outbreak in May 2022. It is important to review known neurologic consequences of both these viruses, as complications […]
Sep 26, 2022
SARS-CoV-2 infection drives an inflammatory response in human adipose tissue through infection of adipocytes and macrophages
Science – Obesity, characterized by chronic low-grade inflammation of the adipose tissue, is associated with adverse coronavirus disease 2019 (COVID-19) outcomes, yet the underlying mechanism is unknown. To explore whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection of adipose tissue contributes to pathogenesis, we evaluated COVID-19 autopsy cases and deeply profiled the response of […]
Sep 25, 2022