Category: Published Research
The transcriptional regulator CtrA controls gene expression in Alphaproteobacteria phages: Evidence for a lytic deferment pathway
Frontiers in Microbiology – Pilitropic and flagellotropic phages adsorb to bacterial pili and flagella. These phages have long been used to investigate multiple aspects of bacterial physiology, such as the cell cycle control in the Caulobacterales. Targeting cellular appendages for adsorption effectively constrains the population of infectable hosts, suggesting that phages may have developed strategies […]
Sep 26, 2022
Lingering cardiac involvement in previously well people after mild COVID-19
Nature Medicine – Lingering cardiac symptoms, including exercise intolerance, tachycardia and chest pain, are increasingly recognized as post-acute COVID-19 sequelae1. In patients with a severe course of initial illness, accrued cardiac injury and pre-existing conditions readily explain cardiac symptoms. However, signs of cardiac injury such as elevated troponin levels and structural heart disease are rare […]
Sep 26, 2022
Clinical studies of detecting COVID-19 from exhaled breath with electronic nose
Nature – The COVID-19 pandemic has attracted numerous research studies because of its impact on society and the economy. The pandemic has led to progress in the development of diagnostic methods, utilizing the polymerase chain reaction (PCR) as the gold standard for coronavirus SARS-CoV-2 detection. Numerous tests can be used at home within 15 min or […]
Sep 26, 2022
Monkeypox in a Young Infant
CDC – In August 2022, the Florida Department of Health (FDOH) was notified of a suspected case of monkeypox in an infant aged <2 months who was admitted to a Florida hospital with a rash and cellulitis. This case report highlights findings from the related epidemiologic investigation and describes the public health actions taken. This […]
Sep 26, 2022
Neurologic Complications of Smallpox and Monkeypox
JAMA Neurology – Orthopox viruses include smallpox virus, a once feared but now eradicated virus, as well as monkeypox virus. Monkeypox is an emerging virus initially isolated in 1958, previously unrecognized outside sub-Saharan Africa until a worldwide outbreak in May 2022. It is important to review known neurologic consequences of both these viruses, as complications […]
Sep 26, 2022
SARS-CoV-2 infection drives an inflammatory response in human adipose tissue through infection of adipocytes and macrophages
Science – Obesity, characterized by chronic low-grade inflammation of the adipose tissue, is associated with adverse coronavirus disease 2019 (COVID-19) outcomes, yet the underlying mechanism is unknown. To explore whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection of adipose tissue contributes to pathogenesis, we evaluated COVID-19 autopsy cases and deeply profiled the response of […]
Sep 25, 2022
SARS-CoV-2 Omicron and its current known unknowns: A narrative review
Pub Med – The emergence of the SARS-CoV-2 Omicron variant (B.1.1.529) has created great global distress. This variant of concern shows multiple sublineages, importantly B.1.1.529.1 (BA.1), BA.1 + R346K (BA.1.1), and B.1.1.529.2 (BA.2), each with unique properties. However, little is known about this new variant, specifically its sub-variants. A narrative review was conducted to summarise […]
Sep 24, 2022
Mixing patterns and the spread of pandemics
Nature – Integrating social mixing data into epidemic models can help policy makers better understand epidemic spread. However, empirical mixing data might not be immediately available in most populations. In a recent work, a network model methodology is proposed to construct micro-level social mixing structure when empirical data are not available.
Sep 23, 2022
Reinfections with Different SARS-CoV-2 Omicron Subvariants, France
CDC – We describe 188 patients in France who were successively infected with different SARS-CoV-2 Omicron subvariants, including BA.1, BA.2, and BA.5. Time between 2 infections was <90 days for 50 (26.6%) patients and <60 days for 28 (14.9%) patients. This finding suggests that definitions for SARS-CoV-2 reinfection require revision.
Sep 23, 2022
Pulmonary Dysfunction after Pediatric COVID-19
Radiology – Long COVID occurs in lower frequency in children and adolescents than in adults. Morphologic and free-breathing phase-resolved functional low-field MRI may identify persistent pulmonary manifestations after SARS-CoV-2 infection.
Sep 23, 2022