Enteroviral molecular biology.
My lab's primary interest focuses on understanding the biology of a common human enterovirus called coxsackievirus B3 (CVB3). There are 6 CVB serotypes and while we use CVB3 as our model, the work is applicable to the other serotypes. Past work has described molecular approaches to effective attenuation of the virus' pathogenesis, work that could be applied to the design of safe attenuated vaccines for these and/or other human enteroviruses. Read more
Please see Dr. Tracy's laboratory webpage and the Enterovirus Research Group for further details.
Education and Training
B.A., University of California, San Diego, 1972
Ph.D., Department of Biology, University of California, San Diego, 1979
Pharmacology and Physician's Assistant students: Lectures on Virology
Graduate students: Virology course co-organizer
Editorial Boards: Journal of Virology (2006-2009), Journal of Medical Virology (1994-)
Smithee S, Tracy S, Chapman NM. Reversion to wildtype of a mutated and nonfunctional coxsackievirus B3CRE(2C). Virus Research 2016 220:136-149. PMID: 27130630
Jaramillo L, Smithee S, Tracy S, Chapman NM. Domain I of the 5′ non-translated genomic region in coxsackievirusB3 RNA is not required for productive replication. Virology 2016 496:127-130.
Carson SD, Tracy S, Kaczmarek ZG, Alhazmi A, Chapman NM. Three capsid amino acids notably influence coxsackie B3 virus stability. J Gen Virol. 2016 Jan;97(1):60-8. doi: 10.1099/jgv.0.000319. Epub 2015 Oct 20. PMID:26489722
Smithee S, Tracy S, Chapman NM. Mutational disruption of the CRE(2C) in coxsackievirus B3 leads to 5’ terminal genomic deletions. J Virol. 2015 Dec;89(23):11761-72. doi: 10.1128/JVI.01308-15. Epub 2015 Sep 9. PMID:26355088 PMCID:PMC4645312
Chapman NM, Coppieters K, von Herrath M, Tracy S. The microbiology of human hygiene and its impact on type 1 diabetes. Islets. 2012 Jul-Aug;4(4):253-61. doi: 10.4161/isl.21570. Epub 2012 Jul 1. PMCID:PMC3496651
Coppieters K, Wiberg A, Tracy S, and von Herrath (2012) The role of viruses in type 1 diabetes: a difﬁcult dilemma. Immunology in the clinic review series: Focus on type 1 diabetes and viruses. Clin Exp Immunol 168:5-11.
McDonald T, Drescher KM, Weber A and Tracy S (2012) Creatinine inhibits bacterial replication. J Antibiotics 2012 Feb 1. doi: 10.1038/ja.2011.131. [Epub ahead of print]
Tracy S, Chapman NM and Drescher KM (2011) Enteroviruses and type 1 diabetes. Diabetes Metab Res Rev 27:820-823.
Tracy S, Drescher KM, Jackson JD, Kim K, Kono K (2010) Enteroviruses, hygiene and type 1 diabetes: a complex relationship. Rev Med Virol 20:106-116
Tracy S and Chapman NM (2010) Group B coxsackievirus diseases. In: The Picornaviruses. E. Ehrenfeld, E. Domingo and R.P. Roos, eds. ASM Press, Washington DC.
Chapman N, Kim K-S, Oka K, Kim K, Tracy S (2008) 5' terminal deletions in the genome of a coxsackievirus B2 strain occurred naturally in human heart. Virology 375:480-491.
Tracy S, Drescher KM, Oberste M.S., eds. (2008) The Coxsackie B Viruses. Curr Top Microbiol Immunol. vol. 323.
Drescher KM and Tracy S (2008) The CVB and etiology of type 1 diabetes. Curr Top Microbiol Immunol. 323:259-274.
Tracy S and Gauntt C (2008) Group B coxsackievirus virulence. Curr Top Microbiol Immunol. 323:49-66.
Kim, K-S, Chapman NM, Tracy S (2008) Replication of coxsackievirus B3 in primary cell cultures generates novel viral genomic deletions. J Virol. 82(4):2033-2037
For a detailed list of publications, click here.