Maher Y. Abdalla, Ph.D.

Department Affiliations
Assistant Professor

Interests
Oxidative stress and free radical biology, Microbial infections, Tumor immunology, and Cancer biology.

Research
I have been investigating the role of free radicals and reactive oxygen species (ROS) in cancer and the infection process since my Ph.D. work at the University of Iowa, and have continued this work as faculty member. I have also worked on molecular immunology and cancer biology at the NIH. I am currently conducting research in the fields of ROS, immune cells, and virulence factors associated with bacterial infection. In addition, I am studying the role of iron intake and metabolism in the pathogenicity associated with Mycobacterium tuberculosis that grow and replicate in human macrophages, with emphasis on identifying strategies to boost the efficacy of disease treatment.

Education and Training
B.Sc.,  Kuwait University, Kuwait City, Kuwait, 1989
M.Sc., Jordan University of Science and Technology, Irbid, Jordan, 1999
Ph.D.,  University of Iowa, College of Medicine, Iowa City, Iowa, USA, 2003
Post-Doctoral Fellowship, University of Iowa, Iowa City, Iowa, USA, 2004
Visiting Scientist, Center for Cancer Research (CCR), National Cancer Institute (NCI)/National Institute of Health (NIH), Bethesda, MD, 2009-2011  

National Activities
Society for Free Radical Biology and Medicine
American Association for Cancer Research

Notable Publications
Abdalla M.Y., Ahmad I.M., Switzer B., Britigan B.E. Induction of heme oxygenase-1 contributes to survival of Mycobacterium abscessus in human macrophages-like THP-1 cells. Redox Biol. 328-339, 2015.

Abu-Eid R., Samara R.N., Ozbun L., Abdalla M.Y., Berzofsky J.A., Friedman K.M., Mkrtichyan M., Khleif S.N. Selective inhibition of regulatory T cells by targeting PI3K-Akt pathway. Cancer Immunol Res. 2014.

Olakanmi O., Kesavalu B., Abdalla M.Y., Britigan B.E. Iron acquisition by Mycobacterium tuberculosis residing within myeloid dendritic cells. Microb Pathog. 65, 21–28. 2013.

Olakanmi O., Kesavalu B., Pasula R., Abdalla M.Y., Schlesinger L.S., Britigan B.E. Gallium Nitrate is Efficacious in Murine Models of Tuberculosis and Inhibits Key Bacterial Fe-Dependent Enzymes. Antimicrob Agents Chemother. 57 (12), 6074-6080. 2013

Abdalla M.Y., Mathahs M.M., Ahmad I.M. Reduced heme oxygenase-1 expression in steatotic livers infected with hepatitis C virus. European Journal of Internal Medicine.  Oct;23(7):649-55, 2012.

Mkrtichyan M., Najjar Y.G., Raulfs E.C., Abdalla M.Y., Samara R., Rotem-Yehudar R.,Cook L., Khleif S.N. Anti-PD-1 synergizes with cyclophosphamide to induce potent anti-tumor vaccine effects through novel mechanisms. Eur J Immunol. Oct;41(10):2977-86. PubMed PMID:21710477, 2011.

Abdalla M.Y., Fawzi M., Al-Maloul S.R., El-Banna N., Tayyem R.F., Ahmad I.M. Increased oxidative stress and iron overload in Jordanian β-thalassemic children. Hemoglobin. 35(1):67-79. PubMed PMID: 21250883, 2011.

Ahmad I.M., Britigan B.E., Abdalla M.Y. Oxidation of thiols and modification of redox-sensitive signaling in human lung epithelial cells exposed to Pseudomonas pyocyanin. J Toxicol Environ Health A. 74(1):43-51. PubMed PMID: 21120747, 2011.

Abu-Surrah A.S., Abu Safieh K.A., Ahmad I.M., Abdalla M.Y., Ayoub M.T., Qaroush A.K.,Abu-Mahtheieh A.M. New palladium(II) complexes bearing pyrazole-based Schiff base ligands: synthesis, characterization and cytotoxicity. Eur J Med Chem. Feb;45(2):471-5. PubMed PMID: 19913953, 2010.

Tahtamouni L.H., Mustafa N.H., Alfaouri A.A., Hassan I.M., Abdalla M.Y., Yasin S.R. Prevalence and risk factors for anabolic-androgenic steroid abuse among Jordanian collegiate students and athletes. Eur J Public Health. Dec;18(6):661-5. PubMed PMID: 18603598, 2008.

Ahmad I.M., Abdalla M.Y., Aykin-Burns N., Simons A.L., Oberley L.W., Domann F.E., Spitz D.R. 2-Deoxyglucose combined with wild-type p53 over expression enhanced cytotoxicity in human prostate cancer cells via oxidative stress. Free Radic BiolMed. Mar 1;44(5):826-34. PubMed PMID: 18155176; PubMed Central PMCID: PMC2350201, 2008.

Abdalla M.Y., Ahmad I.M., Spitz D.R., Schmidt W.N., Britigan B.E. Hepatitis C virus-core and non structural proteins lead to different effects on cellular antioxidant defenses. J Med Virol. Aug;76(4):489-97. PubMed PMID: 15977232, 2005.

Abdalla M.Y., Britigan B.E., Wen F., Icardi M., McCormick M.L., LaBrecque D.R., Voigt M., Brown K.E., Schmidt W.N. Down-regulation of heme oxygenase-1 by hepatitis C virus infection in vivo and by the in vitro expression of hepatitis C core protein. JInfect Dis. Sep 15;190(6):1109-18. PubMed PMID: 15319861, 2004.

Wen F., Abdalla M.Y., Aloman C., Xiang J., Ahmad I.M., Walewski J., McCormick M.L.,Brown K.E., Branch A.D., Spitz D.R., Britigan B.E., Schmidt W.N. Increased prooxidant production and enhanced susceptibility to glutathione depletion in HepG2 cells co-expressing HCV core protein and CYP2E1. J Med Virol. Feb;72(2):230-40.PubMed PMID: 14695664, 2004.

O'Malley Y.Q., Abdalla M.Y., McCormick M.L., Reszka K.J., Denning G.M., Britigan B.E. Subcellular localization of Pseudomonas pyocyanin cytotoxicity in human lung epithelial cells. Am J Physiol Lung Cell Mol Physiol.  Feb;284(2):L420-30. PMID: 12414438, 2003.

For a detailed list of publications, click here