Jie Chen, M.D., Ph.D.

Department Affiliations
Assistant Professor

Interests
Neuropathology

Education and Training
M.D., Taishan Medical University, Tai’an, China, 2002
Ph.D., Ehime University Graduate School of Medicine, Ehime, Japan, 2008
Residency, Anatomic Pathology, Washington University School of Medicine, St. Louis, MO, 2017
Fellowship, Neuropathology, Washington University schoolf of medicine, St. Louis, MO, 2019

Notable Publications
Ly CV, Koenig L, Christensen J, Gordon B, Beaumont H, Dahiya S, Chen J, Su Y, Nelson B, Jockel-Balsarotti J, Drain C, Jerome G, Morris JC, Fagan AM, Harms MB, Benzinger TLS, Miller TM, MD, Ances BM. Tau positron emission tomography imaging in C9orf72 hexanucleotide repeat expansion carriers. Ann Clin Transl Neurol. Submitted.

Nishimune H, Numata T, Chen J, Aoki Y, Wang Y, Starr MP, Mori Y, Stanford JA. Active zone protein Bassoon co-localizes with presynaptic calcium channel, modifies channel function, and recovers from aging related loss by exercise. PLoS One. 2012;7(6):e38029.

Mori S, Yamada S, Kubo S, Chen J, Matsuda S, Shudou M, Maruyama N, Shigemoto K. Divalent and monovalent autoantibodies cause dysfunction of MuSK by distinct mechanisms in a rabbit model of myasthenia gravis. J Neuroimmunol. 2012 Mar;244(1-2):1-7.

Clarke GL*, Chen J*, Nishimune H. Presynaptic active zone density during development and synaptic plasticity. Front Mol Neurosci. 2012 Feb 15;5:12. (*equal contributors)

Chen J, Mizushige T, Nishimune H. Active zone density is conserved during synaptic growth but impaired in aged mice. J Comp Neurol. 2012 Feb 1;520(2):434-52.

Xue B, Chen J*, Gao H, Saito S, Kobayashi N, Shimokawa T, Nabeka H, Sano A, Matsuda S. Chronological changes in prosaposin in the developing rat brain. Neurosci Res. 2011 2011 Sep;71(1):22-34. (*corresponding author) (one figure was selected as cover image)

Chen J, Billings SE, Nishimune H. Calcium channels link the muscle-derived synapse organizer laminin beta 2 to Bassoon and CAST/Erc2 to organize presynaptic active zones. J Neurosci. 2011;31(2):512-25. (highlighted as “This Week in The Journal” article)

Smittkamp S, Spalding H, Brown J, Gupte A, Chen J, Nishimune H, Geiger P, and Stanford J.  Measures of bulbar and spinal motor function, muscle innervation, and mitochondrial function in ALS rats. Behav Brain Res. 2010.;211(1):48-57.

Shigemoto K, Kubo S, Chen J, Hato N, Abe Y, Ueda N, Kobayashi N, Kameda K, Mominoki K, Miyazawa A, Ishigami A, Matsuda S, Maruyama N. Myasthenia gravis experimentally induced with muscle-specific kinase. Ann NY Acad Sci. 2008;1132:93-8.

Chen J, Saito S, Kobayashi N, Sato K, Terashita T, Shimokawa T, Mominoki K, Miyawaki K, Sano, Matsuda S. Expression patterns in alternative splicing forms of prosaposin mRNA in the rat facial nerve nucleus after facial nerve transection. Neurosci Res. 2008;60:82-94. 

For a detailed list of publications, click here.