Basic and transitional research with the goal of identifying and evaluating novel targets for therapy in gastrointestinal tumors with K-Ras mutations.
GI tract, liver, and solid organ transplant pathology
Education and Training
Fellowship, 2016-2017: Gastrointestinal and Transplant Pathology, University of Nebraska Medical Center, Omaha, NE
Residency, 2013-2016: Anatomic Pathology Residency, Indiana University, Indianapolis, IN
M.D., Ph.D. 2005-2013: University of Nebraska Medical Center
B.S. 2001-2005: University of Northern Iowa, Cedar Falls, IA, Summa Cum Laude
Resident and medical student education
Neilsen BK, Frodyma DE, Lewis RE, Fisher KW. KSR as a therapeutic target for Ras-dependent cancers. Expert Opin Ther Targets. 2017 May;21(5):499-509.
Fisher KW, Zhang S, Wang M, Montironi R, Wang L, Baldrige LA, Wang JY, MacLennan GT, Williamson SR, Lopez-Beltran A, Cheng L: TMPRSS2-ERG gene fusion is rare compared to PTEN deletions in stage T1a prostate cancer. Molecular Carcinogenesis 2017 Mar;56(3):814-820.
McCall JL, Gehring D, Clymer BK, Fisher KW, Das B, Kelly DL, Kim H, White MA, Lewis RE. KSR1 and EPHB4 regulate Myc and PGC1β to promote survival of human colon tumor cells. Mol Cell Biol. 2016 Jun 6 (Epub).
Wang L, Ren F, Wang Q, Baldridge LA, Monn MF, Fisher KW, Sheng W, Zhou X, Du X, Cheng L. Significance of Programmed Death Ligand 1 (PD-L1) Immunohistochemical Expression in Colorectal Cancer. Mol Diagn Ther. 2016 Apr;20(2):175-81.
Fisher KW Lin J. MicroRNA in inflammatory bowel disease: Translational research and clinical implication. World J of Gastroenterol. 2015 Nov 21;21(43): 12274-12282.
Fisher KW, Das B, Kim HS, Clymer B, Gehring D, Smith D, Costanzo-Garvey D, Fernandez M, Brattain M, Kelly D, MacMillan J, White MA, Lewis RE. AMPK promotes aberrant PGC1β expression to support human colon tumor cell survival. Mol Cell Biol. 2015 Nov 15;35(22):3866-79.
Fisher KW, Montironi R, Lopez Beltran A, Moch H, Wang L, Scarpelli M, Williamson SR, Koch MO, Cheng L. Molecular Foundations for Personalized Therapy in Prostate Cancer. Curr Drug Targets. 2015;16 (2):103-14.
Fisher, KW, Saxena R. Drug induced liver injury. Arch Pathol Lab Med. 2015 Jul; 139(7):876-87.