Tammy L. Kielian, Ph.D.

Department Affiliations
Professor
Choudari Kommineni, D.V.M., Ph.D. Professor of Pathology (2014)

Interests
Immunology, Infectious Diseases, Neuroimmunology, Juvenile Batten Disease, Glial biology, Translational therapeutics
Dr. Kielian's laboratory for more details of her research. 
 
Education and Training
B.S., University of Nebraska-Lincoln, Lincoln NE (Biological Sciences), 1991
M.S., Kansas State University, Manhattan, KS (Immunology), 1994
Ph.D., Univ. Kansas Medical Center, Kansas City, KS (Microbiology), 1998
Post-doctoral training, Dartmouth Medical School, Lebanon, NH (Neuroimmunology), 1998-2001

Teaching Activities
Graduate students- Graduate student mentor
Advanced Immunology (PATH 955)
Bacterial Pathogenesis (PAMM 950)
Receptors and Cell Signaling (PHAR 901)

National Activities

Co-Chair, Gordon Research Conference on Staphylococcal Diseases, Lucca (Barga), Italy, 2017
Chair, FASEB Scientific Research Conference on Neuroimmunology, Big Sky, MT, 2016
Scientific Program Committee, 17th International Symposium on Staphylococci and Staphylococcal Infections (ISSSI), Seoul, Korea, 2016
Chair, NIH/NINDS NST-2 review panel for MD/PhD and K99/R00 applications, 2014-2016 and Full Member 2011-2014
Deputy Chief Editor and Member of Editorial Board, Journal of Neurochemistry 
Editorial Board, Journal of Neuroinflammation 
Jordi Folch Pi Memorial Award from the American Society for Neurochemistry (ASN) for outstanding contributions to Neuroscience Research 
Scientific Advisory Board, UC Riverside Center for Glial Neuronal Interactions (CGNI)

Local Awards

Graduate Student Association Distinguished Mentor Award, University of Nebraska Medical Center, 2015
UNeMed Innovator of the Year Award, University of Nebraska Medical Center, 2015
UNeMed Emerging Inventor award, University of Nebraska Medical Center, 2012
UNMC Distinguished Scientist award, University of Nebraska Medical Center, 2010 

Notable Publications

Google Scholar

Scherr, T.D., Hanke, M.L., Huang, O., James, D.B.A., Horswill, A.R., Bayles, K.W., Fey, P.D., Torres, V.J., and Kielian, T. Staphylococcus aureus biofilms induce macrophage dysfunction through leukocidin AB and α-toxin, mBio, vol. 6 no. 4 e01021-15, 2015.

Heim, C.E., Vidlak, D., and Kielian, T. Interleukin-10 produced by myeloid-derived suppressor cells (MDSCs) contributes to bacterial persistence during S. aureus orthopedic biofilm infection, J. Leuk. Biol., 98:1003-1013, 2015. Article selected for Press Release: http://www.sciencedaily.com/releases/2015/12/151201115041.htm

Heim, C.E.*, Vidlak, D.*, Scherr, T.D., Hartman, C.W., Garvin, K. L., and Kielian, T. Interleukin-12 promotes myeloid-derived suppressor cell (MDSC) recruitment and bacterial persistence during S. aureus orthopedic implant infection. J. Immunol., 194:3861-3872, 2015. *Equal contributions. PMID: 25762781

Burkovetskaya*, M., Karpuk*, N., Xiong, J., Bosch, M., Boska, M.D., Takeuchi, H., Suzumura, A., and Kielian, T. Evidence for aberrant astrocyte hemichannel activity in Juvenile Neuronal Ceroid Lipofuscinosis (JNCL). PLoS ONE, 9(4):e95023, 2014. *Equal contributions

Heim, C.E., Vidlak, D., Scherr, T.D., Kozel, J.A., Holzapfel, M., Muirhead, D.E., and Kielian, T. Myeloid-derived suppressor cells (MDSCs) contribute to S. aureus orthopedic infection. J. Immunol., 192:3778-3792, 2014.  Image Selected for Journal Cover

Xiong, J. and Kielian, T. Microglia in Juvenile Neuronal Ceroid Lipofuscinosis (JNCL) are primed towards a proinflammatory phenotype. J. Neurochem., 127:245-258, 2013.

Karpuk, N., Burkovetskaya, M., Fritz, T., Angle, A., and Kielian, T. Neuroinflammation leads to region-dependent alterations in astrocyte gap junction communication and hemichannel activity. J. Neurosci., 31:414-425, 2011.

Thurlow, L.R., Hanke, M.L., Fritz, T., Angle, A., Aldrich, A., Williams, S.H., Engebretsen, I.L., Bayles, K.W., Horswill, A.R., and Kielian, T. Staphylococcus aureus biofilms prevent macrophage phagocytosis and attenuate inflammation in vivoJ. Immunol., 186:6585-6596, 2011. Image Selected for Journal Cover 

For a detailed list of publications click here.