Audrey J. Lazenby, M.D.

Department Activities
Professor
Director, Anatomic Pathology

Interests
Gastrointestinal Pathology, General Surgical Pathology

My research interests in gastrointestinal pathology include collagenous and lymphocytic colitis, ulcerative colitis, Crohn's disease, infectious diseases of the GI tract, and other non-neoplastic GI disorders. Fatty liver disease, associated with obesity, is also a focus.

Education and Training
B.S., Magna Cum Laude, Davidson College, Davidson, NC, 1978
M.D., The Johns Hopkins University School of Medicine, Baltimore, Maryland, 1982
Residency, Anatomic Pathology, Washington University, School of Medicine, St. Louis, Missouri, 1982-1985
Fellowship, Surgical Pathology, University of North Carolina School of Medicine, Chapel Hill, North Carolina 1985-1986
Fellowship, Gastrointestinal Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, 1986-1988

Teaching Activities
Medical Students: Lectures and laboratories on esophageal pathology, stomach pathology, non-neoplastic small and large bowel pathology, colon carcinoma
Resident Education:  Gastrointestinal pathology, general surgical pathology
Practicing Pathologists' Education (National):  Lecturer at GI Pathology Society sessions of USCAP and International Association of Pathologists (IAP).  Invited speaker at regional CME courses throughout the country, short course instructor (USCAP), evening specialty conference instructor (USCAP)

National Activities
The United States and Canadian Academy of Pathology (USCAP):  Abstract Review Board 1996-2000, 2002, Platform Moderator, Education Committee 2005-2009
Gastrointestinal Pathology Society: Chairman Training Committee 1992-1995, Secretary Treasurer 1996-1998, Vice-President 1999, President 2000
American Gastroenterologic Association
NCCN Colorectal Cancer Screening Committee, 2008-Present

Notable Publications
Smith BL, Khouchani M, Kakouri M, Lazenby AJ, Watkins K, Tahri A, Rajaram S, Soliman A. Incidence of Gastric Cancer in Marrakech and Casablanca, Morocco. J Cancer Epidemiol.  Vol. 2015, Article ID 704569. doi:10.1155/2015/704569.  PMID: 26576155.

Shukla SK, Gunda V, Abrego J, Haridas D, Mishra A, Souchek J, Chaika NV, Yu F, Sasson AR, Lazenby AJ, Batra SK, Singh PK. MUC16-mediated activation of mTOR and c-Myc reprograms pancreatic cancer metabolism.  Oncotarget. 2015 Jun 3. [Epub ahead of print] PMID: 26046375

Leiphrakpam PD, Rajput A, Mathiesen M, Agarwal E, Lazenby AJ, Are C, Brattain MG,   Chowdhury S. Ezrin expression and cell survival regulation in colorectal cancer. Cell Signal. 2014 May;26(5):868-79. PMID: 24462708.

Liu S, Xiao SY, Plesec TP, Jiang W, Goldblum JR, Lazenby AJ. Collagenous colitis in children and adolescents: study of 7 cases and   literature review. Mod Pathol, 2013 June; 26(6):888-7. PMID: 23348901

Chaika NV, Yu F, Purohit V, Lazenby AJ, DiMaio D, Anderson JM, Yeh JJ, Johnson KR,      Hollingsworth MA, Singh PK.  Differential Expression of Metabolic Genes in Tumor and Stromal Components in Primary and Metastatic Loci in Pancreatic Adenocarcinoma.  PLoS ONE, 2012; 7(3):e32996. Epub 2012 Mar 7. PMID: 22412968

Robert ME, Washington MK, Lee JF, Goldenring JR, Bronner MP, Goldblum JR, Greenson JK, Haber MM, Hart JA, Lamps LW, Lauwers GY, Lewin D, Lazenby AJ, Montgomery E, Crawford JM. Immunohistochemistry does not distinguish between indefinite, low- or high-grade dysplasia in Barrett Esophagus. Am J Clin Pathol, 124:519-527, 2005.

Thompson B, Salzman D, Lazenby AJ, Wilcox CM. Prospective endoscopic evaluation of graft versus host disease: determination of the best diagnostic approach. Bone Marrow Transplantation, 38:371-376, 2006.

Lui X, Lazenby AJ, Siegel GP. Signal transduction cross-talk during colorectal tumorigenesis, Adv Ant Pathol, 13:270-274, 2006.

Kornacki S, Hansen FC, Lazenby AJ.  Graft-versus-host-like colitis associated with malignant thymoma: A case report.  Am J Surg Pathol, 19:224-228, 1995

Golumbek PT, Lazenby AJ, Levitsky HI, Jaffee LM, Karasuyama H, Baker M, Pardoll DM.  Treatment of established renal cancer by tumor cells engineered to secrete Interleukin-4.  Science, 254:713-716, 1991.

Lazenby AJ, Crouch EC, McDonald JA, Kuhn C.  Remodeling of the lung in bleomycin-induced pulmonary fibrosis in the rat.  An immunohistochemical study of laminin, type IV collagen, and fibronectin.  Am Rev Respir Dis, 142:206-214, 1990.

Lazenby AJ, Yardley JH, Giardiello FM, Jessurun J, Bayless TM.  Lymphocytic (“microscopic”) colitis.  A comparative histopathologic study, with particular reference to collagenous colitis.  Hum Pathol, 20:18-28, 1989.

For a detailed list of publications click here.