Prabagaran (Praba) Narayanasamy, Ph.D.

Department Affiliations
Assistant Professor

Interests
Drug design, discovery and development (including drug delivery by nanomedicine) for infectious diseases. Study of physiology and pathogenesis of bacteria and virus towards drug discovery. Design, synthesis, and characterization of substrates, inhibitors, intermediates, products and mechanisms for drug discovery and development.

For more details on Dr. Narayanasamy's research, please visit his webpage.

Education and Training
Ph.D., Indian Institute of Technology, Madras, India, Organic Chemistry, 2002
M.S., Pondicherry University, Pondicherry, India, Chemistry (with Distinction), 1996
P.G.D.S.D., Brilliant Computer Center, Pondicherry, India, Computer Science & Applications (with Distinction), 1994
B.S., Pondicherry University, Pondicherry, India, Chemistry, 1994


Teaching Activities

Lectures in team-taught courses
Pharm 507 – Basic Pharmacology – PA Team taught course – 2014
PAMM 950 – Special topics in drug discovery against infectious diseases – 2016
PAMM 992 – Drug/therapy resistance – 2017 

Coordinator/supervisor
PAMM 992 – Drug/therapy resistance -2017
PAMM 950 – Special topics in drug discovery against infectious diseases – 2016
PEN 950-1 – Special topics in Pharmacology –2013-14
MIP 298 – Introduction to Research, 2010.

Graduate students with supervision of thesis
Joel Frandsen, Ph. D student 3rd year
Yiran Wang, Undergraduate 2013
Courtney Venegas, Undergraduate 2015
Madeline Cloonan, Undergraduate 2016
Dr. Seoung-ryoung Choi, Postdoc 3rd year
Dr. Benson Edagwa, Postdoc 2nd year

National Activities
American Chemical Society
Nanomedicine American Society

Notable Publications
Frandsen, J., and Narayanasamy, P. (2017). Flavonoid Enhances the Glyoxalase Pathway in Cerebellar Neurons to Retain Cellular Functions. Sci. Rep. 7(1):5126. doi: 10.1038/s41598-017-05287-z

Choi, S., Britigan, B. Moran, D and Narayanasamy, P. (2017). Gallium Nanoparticles Facilitate Phagosome Maturation and Inhibit Growth of Virulent Mycobacterium tuberculosis in Macrophages. PLoS One 12(5): e0177987. https://doi.org/10.1371/journal.pone.0177987

Choi, S., Britigan, B. and Narayanasamy, P. (2017). Ga(III) Nanoparticles Inhibit Growth of Both TB and HIV and Release of IL-6 and IL-8 in Co-Infected Macrophages. Antimicrob. Agents Chemother. 61, 4, pii: e02505-16. doi: 10.1128/AAC.02505-16.

Choi, S., Frandsen, J. and Narayanasamy, P. (2017). Novel long-chain compounds with both immunomodulatory and MenA inhibitory activities against Staphylococcus aureus and its biofilm. Sci. Rep. 7, 40077; doi: 10.1038/srep40077

Choi, S., Larson, M. A., Hinrichs, S. H.,  Narayanasamy, P. (2016). Development of potential broad spectrum antimicrobials using C2 symmetric 9-fluorenone alkyl amine   Bioorganic & Medicinal Chemistry Letters, 26, 1997-1999.

Choi, S., Larson, M. A., Hinrichs, S. H.,  Bartling, A. M.,  Frandsen, J., Narayanasamy, P. (2016). Discovery of bicyclic inhibitors against menaquinone biosynthesis. Future Medicinal Chemistry, 8(1), 11-16.  PMID: 26699277

Narayanasamy, P. (2015) MEP pathway: A novel Pathway for New antibiotics. Chem Sci J. 6: e111. doi:10.4172/2150-3494.1000e111. (Editorial)

Narayanasamy, P., Switzer, B.L. & Britigan, B.E. (2015) Prolonged-acting, Multi-targeting Gallium Nanoparticles Potently Inhibit Growth of Both HIV and Mycobacteria in Co-Infected Human Macrophages. Sci. Rep. 5, 8824; DOI: 10.1038/ srep08824.

Edagwa, B., Guo, D., Puligujja, P., Chen, H., McMillan, J., Liu, X., Gendelman, H., Narayanasamy, P. (2014) Long-acting antituberculous therapeutic nanoparticles target macrophage endosomes. FASEB J., 28(12), 5071-82.

Edagwa, B., Narayanasamy, P*. (2013), Synthesis of chirally pure 1-deoxy-D-xylulose-5-phosphate : A substrate for IspC assay to determine M. tb inhibitor. Chem Sci J 4:079. doi: 10.4172/2150-3494.1000079.

Edagwa, B., Wang, Y., Narayanasamy, P*. (2013), Synthesis of azide derivative and discovery of glyoxalase pathway inhibitor against pathogenic bacteria, Bioorganic & Medicinal Chemistry Letters, 23(22), 6138-6140.

Epstein AA, Narayanasamy P, Dash PK, High R, Bathena SP, Gorantla S, Poluektova LY, Alnouti Y, Gendelman HE, Boska MD. (2013) Combinatorial assessments of brain tissue metabolomics and histopathology in rodent models of human immunodeficiency virus infection. J Neuroimmune Pharmacol. 8(5): 1224-38.

I. Kadiu, P. Narayanasamy, P. Das, W. Zhang, H. Gendelman. (2012) Biochemical and biologic characterization of exosomes and microvesicles as facilitators of HIV-1 infection in macrophages. J. Immunology. 744-754.

P. Narayanasamy*,H. Eoh, P. J. Brennan, and D. C. Crick. (2010) Synthesis of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate and kinetic studies of Mycobacterium Tuberculosis IspF. Chemistry and Biology, 17, 117-122.

P. Narayanasamy, H. Eoh, A. C. Brown, T. Parish, P. J. Brennan, and D. C. Crick.  (2009). Expression and characterization of soluble 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase from bacterial pathogens. Chemistry and Biology, 16, 1230-1239.

P. Narayanasamy,* H. Eoh, and D. C. Crick. (2008). Chemoenzymatic synthesis of 4-Diphosphocytidyl-2-C-methyl-D-erythritol: A substrate for IspE. Tetrahedron Letters, 4461-4463.

P. Narayanasamy* and D. C. Crick. (2008). Enantiomeric Synthesis of 2-C-Methyl-D-erythritol 2, 4- cyclodiphosphate. Heterocycles, 76, 243.

For a detailed list of publications, click here.