Caroline L. Ng, PhD

Department Affiliations
Assistant Professor

Interests
Biology and pathogenesis of Plasmodium falciparum, genetic and molecular mechanisms underlying drug resistance

Education and Training
BA, Barnard College of Columbia University, 2003 (Biology)
PhD, Mount Sinai School of Medicine, 2011 (Biomedical Sciences)
Post-Doctoral Research Scientist, Columbia University Medical Center, 2011-2015
Associate Research Scientist, Columbia University Medical Center, 2015-2017

Notable publications (last 5 years)
Rosenthal MR and Ng, CL. A proteasome mutation sensitizes P. falciparum Cam3.II K13C580Y parasites to DHA and OZ439. ACS Inf Dis (2021) 7(7): 1923-1931. PMID: 33971094. 

Firestone TM, Oyewole OO, Reid SP, Ng CL. Repurposing Quinoline and Artemisinin Antimalarials as Therapeutics for SARS-CoV-2: Rationale and Implications. ACS Pharmacol Transl Sci. (2021) Apr 9;4(2):613-623. PMID: 33855275. 

Rosenthal MR and Ng, CL. Plasmodium falciparum artemisinin resistance: the effect of heme, protein damage, and parasite cell stress response. ACS Inf Dis (2020) 6(7):1599-1614. PMID: 32324369. 

Stokes BH, Yoo E, Murithi JM, Luth MR, Afanasyev P, da Fonseca PCA, Winzeler EA, Ng CL*, Bogyo M*, Fidock DA*. Covalent Plasmodium falciparum-selective proteasome inhibitors exhibit a low propensity for generating resistance in vitro and synergize with multiple antimalarial agents. PLoS Pathog (2019) 15(6):e1007722. PMID: 31170268. PMCID: PMC6553790. * Corresponding authors. † Selected as a Featured Article, featured on Journal home page, and accompanied by press release. 

Ng CL, Fidock DA. Plasmodium falciparum in vitro drug resistance selections and gene editing. Methods Mol Biol (2019) 2013:123-140. PMID: 31267498. 

Ng CL, Fidock DA, Bogyo M. Protein degradation systems as anti-malarial therapeutic targets. Trends Parasitol (2017) 33(9): 731-743. PMID: 28688800.

For a detailed list of publications, click here