Scot Ouellette, PhD

Department Affiliations
Professor

Interests
Chlamydial microbiology: bacterial cell division, gene regulation, host-pathogen interactions
Ouellette Laboratory

Education and Training
Pasteur Foundation Post-doctoral fellow, Microbiology, Institut Pasteur, 2013
Post-doctoral Fellow, Cellular Microbiology, Imperial College London, 2010
PhD, Molecular Sciences, University of Tennessee Health Science Center, 2006
BS, Medical Microbiology and Immunology, University of Wisconsin, 2000
BS, Molecular Biology, University of Wisconsin, 2000

Publications (in the last 3 years)
Reuter, J., Otten, C., Jacquier, N., Lee, J., Mengin-Lecreulx, D., Löckener, I., Kluj, R., Mayer, C., Corona, F., Dannenberg, J., Aeby, S., Bühl, H., Greub, G., Vollmer, V., Ouellette, S.P., Schneider, T., and Henrichfreise, B. (2023). An NlpC/P60 protein catalyzes a key step in peptidoglycan recycling at the intersection of energy recovery, cell division, and immune evasion in the intracellular pathogen Chlamydia trachomatis. PLoS Pathogens. in press PMID: pending

De Campos, L.J., Seleem, M.A., Feng, J., Pires de Oliveira, K.M., dos Santos, J.V.A., Hayer, S., Clayton, J.B., Kathi, S., Fisher, D.J., Ouellette, S.P., and Conda-Sheridan, M. (2023). Design, biological evaluation, and computer-aided analysis of dihydrothiazepines as selective antichlamydial agents. J Med Chem. in press PMID: pending

Riffaud, C., Rucks, E.A., and *Ouellette, S.P. (2023). Tryptophan availability during persistence of Chlamydia trachomatis directly impacts expression of chlamydial cell division proteins. Infect Immun. in press PMID: 36645295

Azadmanesh, J., Seleem, M.A., Struble, L., Wood, N.A., Fisher, D.J., Lovelace, J.J., Artigues, A., Fenton, A., Borgstahl, G.E.O., Ouellette, S.P., and Conda-Sheridan, M. (2023). The structure of caseinolytic protease subunit ClpP2 reveals a functional model of the caseinolytic protease system from Chlamydia trachomatis. J Biol Chem. 299: 102762. PMID: 36463962

Ayayee, P.A., Wesner, J.S., and Ouellette, S.P. (2022). Geography, taxonomy, and ecological guild: factors impacting freshwater macroinvertebrate gut microbiomes. Ecol Evol. 12: e9663. PMID: 36582772

Wood, N.A., Swoboda, A.R., Blocker, A.M., Fisher, D.J., and *Ouellette, S.P. (2022). Tag-dependent substrate selection of ClpX underlies secondary differentiation of Chlamydia trachomatis. mBio. 13: e0185822. PMID: 36154190

*Ouellette, S.P., Fisher-Marvin, L.A.^, Harpring, M.^, Lee, J.^, Rucks, E.A., and *Cox, J.V. (2022). Localized cardiolipin synthesis is required for the assembly of MreB during the polarized cell division of Chlamydia trachomatis. PLoS Pathog. 18: e1010836. PMID: 36095021

Seleem, M.A., Wood, N.A., Brinkworth, A.J., Manam, S., Carabeo, R.A., Murthy, A.K., *Ouellette, S.P., and *Conda-Sheridan, M. (2022). In vitro and in vivo activity of (trifluoromethyl)pyridines as anti-Chlamydia trachomatis agents. ACS Infect. Dis. 8: 227-241. PMID: 34935346

*Ouellette, S.P., Hatch, N.D., Wood, N.A., Herrera, A.J., and Chaussee, M.S. (2021). Codon-dependent transcriptional changes in response to tryptophan limitation in the tryptophan auxotrophic pathogens Chlamydia trachomatis and Streptococcus pyogenes. mSystems 6: e01269-21. PMID: 34904862

Brockett, M.^, Lee, J.^, Cox, J.V., *Liechti, G.W., and *Ouellette, S.P. (2021). A Dynamic Ring-Forming Bactofilin Is Critical for Maintaining Cell Shape in Chlamydia trachomatis. (^Contributed equally.)  Infect. Immun. 89: e00203-21. 

*Ouellette, S.P., Blay, E.A.^, Hatch, N.D.^, Fisher-Marvin, L.A. (2021). CRISPR Interference to Inducibly Repress Gene Expression in Chlamydia trachomatis. (^Contributed equally.) Infect. Immun. 89: e00108-21.

Olson-Wood, M.G., Jorgenson, L.M., *Ouellette, S.P., and *Rucks, E.A. (2021). Inclusion Membrane Growth and Composition Is Altered by Overexpression of Specific Incs from Chlamydia trachomatis L2 Transformed Strains. Infect. Immun. 89: e00094-21.

Bui, D.-C.^, Jorgenson, L.A.^, Ouellette, S.P., and Rucks, E.A. (2021). Eukaryotic SNARE VAMP3 dynamically interacts with multiple chlamydial inclusion membrane proteins. Infect. Immun. 89: e00409-20. (^Contributed equally.)

For a detailed list of publications, click here