Scot Ouellette, PhD

Department Affiliations
Associate Professor

Interests
Chlamydial microbiology: bacterial cell division, gene regulation, host-pathogen interactions
Ouellette Laboratory

Education and Training
Pasteur Foundation Post-doctoral fellow, Microbiology, Institut Pasteur, 2013
Post-doctoral Fellow, Cellular Microbiology, Imperial College London, 2010
PhD, Molecular Sciences, University of Tennessee Health Science Center, 2006
BS, Medical Microbiology and Immunology, University of Wisconsin, 2000
BS, Molecular Biology, University of Wisconsin, 2000

Publications (in the last 3 years)
Brockett, M.^, Lee, J.^, Cox, J.V., *Liechti, G.W., and *Ouellette, S.P. (2021). A Dynamic Ring-Forming Bactofilin Is Critical for Maintaining Cell Shape in Chlamydia trachomatis. (^Contributed equally.)  Infect. Immun. 89: e00203-21. 

*Ouellette, S.P., Blay, E.A.^, Hatch, N.D.^, Fisher-Marvin, L.A. (2021). CRISPR Interference to Inducibly Repress Gene Expression in Chlamydia trachomatis. (^Contributed equally.) Infect. Immun. 89: e00108-21.

Olson-Wood, M.G., Jorgenson, L.M., *Ouellette, S.P., and *Rucks, E.A. (2021). Inclusion Membrane Growth and Composition Is Altered by Overexpression of Specific Incs from Chlamydia trachomatis L2 Transformed Strains. Infect. Immun. 89: e00094-21.

Bui, D.-C.^, Jorgenson, L.A.^, Ouellette, S.P., and Rucks, E.A. (2021). Eukaryotic SNARE VAMP3 dynamically interacts with multiple chlamydial inclusion membrane proteins. Infect. Immun. 89: e00409-20. (^Contributed equally.)

Pokorzynski, N.D., Hatch, N.D., Ouellette, S.P., and Carabeo, R.C. (2020). The iron-dependent repressor YtgR is a tryptophan-dependent attenuator of the trpRBA operon in Chlamydia trachomatis. Nature Comm. 11: 6430.

Wood, N.A., Blocker, A.M., Seleem, M.A., Conda-Sheridan, M., Fisher, D.J., and *Ouellette, S.P. (2020). The ClpX and ClpP2 orthologs of Chlamydia trachomatis perform discrete and essential functions in organism growth and development. mBio 11: e02016-20.

Cox, J.V., AbdelRahman, Y.M., and Ouellette, S.P. (2020). Penicillin-binding proteins regulate multiple steps in the polarized cell division process of Chlamydia. Sci. Rep. 10: 12588.

*Ouellette, S.P., Lee, J., and Cox, J.V. (2020). Division without binary fission: cell division in the FtsZ-less Chlamydia. J. Bacteriol. 202: e00252-20.

Seleem, M.A., Rodrigues de Almeida, N., Chhonker, Y.S., Murry, D.J., da Rosa Guterres, Z., Blocker, A., Kuwabara, S., Fisher, D.J., Leal, E., Martinefski, M., Bollini, M., Monge, M., *Ouellette, S.P., and *Conda-Sheridan, M. (2020). Synthesis and antichlamydial activity of molecules based on dysregulators of cylindrical proteases. J. Med. Chem. 63: 4370-4387.

Lee, J., Cox, J.V., and *Ouellette, S.P. (2020). Critical role for the extended N-terminus of chlamydial MreB in directing its membrane association and potential interaction with divisome proteins. J. Bacteriol. 202: e00034-20.

Hatch, N.D., and *Ouellette, S.P. (2020). Inhibition of tRNA synthetases induces persistence in Chlamydia. Infect. Immun. 88: e00943-19.

Olson, M.G., *Ouellette, S.P., and *Rucks, E.A. (2020). A meta-analysis of affinity purification-mass spectrometry experimental systems used to identify eukaryotic and chlamydial proteins at the Chlamydia trachomatis inclusion membrane. J. Proteomics 212: 103595.

Madison, J.D., Ouellette, S.P., Schmidt, E., and Kerby, J.L. (2019). Serratia marcescens shapes cutaneous bacterial communities and influences survival of an amphibian host. Proc. R. Soc. B. 286: 20191833.

Olson, M.G., Widner, R., Jorgenson, L.M., Lawrence, A., Lagundzin, D., Woods, N., *Ouellette, S.P., and *Rucks, E.A. (2019). Proximity Labeling to Map Host-Pathogen Interactions at the Membrane of a Bacteria Containing Vacuole in Chlamydia trachomatis Infected Human Cells. Infect. Immun. 87: e00537-19.

Sazama, E.J., Ouellette, S.P., and Wesner, J.S. (2019). Bacterial endosymbionts are common among, but not necessarily within, insect species. Environ. Entomol. 48: 127-133.

 

For a detailed list of publications, click here