Scot Ouellette, PhD

Department Affiliations
Associate Professor

Interests
Chlamydial microbiology: bacterial cell division, gene regulation, host-pathogen interactions
Ouellette Laboratory

Education and Training
Pasteur Foundation Post-doctoral fellow, Microbiology, Institut Pasteur, 2013
Post-doctoral Fellow, Cellular Microbiology, Imperial College London, 2010
PhD, Molecular Sciences, University of Tennessee Health Science Center, 2006
BS, Medical Microbiology and Immunology, University of Wisconsin, 2000
BS, Molecular Biology, University of Wisconsin, 2000

Publications (in the last 3 years)
Wood, N.A., Blocker, A.M., Seleem, M.A., Conda-Sheridan, M., Fisher, D.J., and *Ouellette, S.P. (2020). The ClpX and ClpP2 orthologs of Chlamydia trachomatis perform discrete and essential functions in organism growth and development. mBio 11: e02016-20.

Cox, J.V., AbdelRahman, Y.M., and Ouellette, S.P. (2020). Penicillin-binding proteins regulate multiple steps in the polarized cell division process of Chlamydia. Sci. Rep. 10: 12588.

*Ouellette, S.P., Lee, J., and Cox, J.V. (2020). Division without binary fission: cell division in the FtsZ-less Chlamydia. J. Bacteriol. 202: e00252-20.

Seleem, M.A., Rodrigues de Almeida, N., Chhonker, Y.S., Murry, D.J., da Rosa Guterres, Z., Blocker, A., Kuwabara, S., Fisher, D.J., Leal, E., Martinefski, M., Bollini, M., Monge, M., *Ouellette, S.P., and *Conda-Sheridan, M. (2020). Synthesis and antichlamydial activity of molecules based on dysregulators of cylindrical proteases. J. Med. Chem. 63: 4370-4387.

Lee, J., Cox, J.V., and *Ouellette, S.P. (2020). Critical role for the extended N-terminus of chlamydial MreB in directing its membrane association and potential interaction with divisome proteins. J. Bacteriol. 202: e00034-20.

Hatch, N.D., and *Ouellette, S.P. (2020). Inhibition of tRNA synthetases induces persistence in Chlamydia. Infect. Immun. 88: e00943-19.

Olson, M.G., *Ouellette, S.P., and *Rucks, E.A. (2020). A meta-analysis of affinity purification-mass spectrometry experimental systems used to identify eukaryotic and chlamydial proteins at the Chlamydia trachomatis inclusion membrane. J. Proteomics 212: 103595.

Madison, J.D., Ouellette, S.P., Schmidt, E., and Kerby, J.L. (2019). Serratia marcescens shapes cutaneous bacterial communities and influences survival of an amphibian host. Proc. R. Soc. B. 286: 20191833.

Olson, M.G., Widner, R., Jorgenson, L.M., Lawrence, A., Lagundzin, D., Woods, N., *Ouellette, S.P., and *Rucks, E.A. (2019). Proximity Labeling to Map Host-Pathogen Interactions at the Membrane of a Bacteria Containing Vacuole in Chlamydia trachomatis Infected Human Cells. Infect. Immun. 87: e00537-19.

Sazama, E.J., Ouellette, S.P., and Wesner, J.S. (2019). Bacterial endosymbionts are common among, but not necessarily within, insect species. Environ. Entomol. 48: 127-133.

Wood, N.A., Chung, K., Rodrigues de Almeida, N., Conda-Sheridan, M., Fisher, D.J., and *Ouellette, S.P. (2018). Initial characterization of the two ClpP isoforms of Chlamydia trachomatis suggests unique functionality for each. J. Bacteriol. 201: e00635-18. (Erratum in 201: e00613-19.)

*Ouellette, S.P., Messerli, P.J., Wood, N.A., and Hajovksy, H. (2018). Characterization of chlamydial Rho and the role of Rho-mediated transcriptional polarity during IFNg-mediated tryptophan limitation. Infect. Immun. 86: e00240-18.

Olson, M.G., Goldammer, M., Gauliard, E., Ladant, D., and *Ouellette, S.P. (2018). A Bacterial Adenylate Cyclase-Based Two-Hybrid system compatible with Gateway® cloning. Methods Mol. Biol. 1794: 75-96.

*Ouellette, S.P. (2018). Feasibility of a conditional knockout system for Chlamydia based on CRISPR interference. Front. Cell. Infect. Microbiol. 8:59.

For a detailed list of publications, click here