Marat R. Sadykov, Ph.D.

Department Affiliations
Assistant Professor

Interests
Bacterial genetics, physiology and metabolism

Education and Training
M.Sc., Genetics, Kazan State University, Kazan, Russia, 1991
Ph.D., Molecular Biology, Moscow State University, Moscow, Russia, 1999

National Activities
Member, American Society for Microbiology
Member, American Association for the Advancement of Science
Member, Sigma Xi: The Scientific Research Society

Notable Publications
Gries, C., Sadykov, M., Bulock, L., Chaudhari, S., Thomas, V., Bose, J., and Bayles, K. Potassium uptake modulates Staphylococcus aureus metabolism. mSphere. 1(3): e00125-16, 2016.

Chaudhari, S.S, Thomas, V.C., Sadykov, M.R., Bose, J.L., Ahn, D.J., Zimmerman, M.C., and Bayles, K.W. The LysR-type transcriptional regulator, CidR, regulates stationary phase cell death in Staphylococcus aureus. Mol. Microbiol. 101: 942-953, 2016.

Waters, N.R., Samuels, D.J., Behera, R.K., Livny, J., Rhee, K.Y., Sadykov, M.R., and Brinsmade, S.R. A Spectrum of CodY Activities Drives Metabolic Reorganization and Virulence Gene Expression in Staphylococcus aureus. Mol. Microbiol. 101: 495-514, 2016.

Marshall, D.D., Sadykov, M.R., Thomas, V.C., Bayles, K.W., and Powers, R.  A redox imbalance underlies the fitness defect associated with inactivation of the Pta-AckA pathway in Staphylococcus aureus. J. Proteome Res. 15: 1205-1212, 2016.

Sadykov, M.R. Restriction-Modification Systems as a Barrier for Genetic Manipulation of Staphylococcus aureus. Methods Mol. Biol. 1373:9-23, 2016.

Lehman, M.K., Bose, J.L., Sharma-Kuinkel, B.K., Moormeier, D.E., Endres, J.L., Sadykov, M.R., Biswas, I.,  and Bayles, K.W. Identification of the amino acids essential for LytSR-mediated signal transduction in Staphylococcus aureus and their roles in biofilm-specific gene expression. Mol. Microbiol. 95: 723-737, 2015.

Thomas, V.C., Sadykov, M.R., Chaudhari, S.S., Jones, J., Endres, J. L., Widhelm, T.J., Ahn, J-S., Jawa, R.S., Zimmerman, M.C., and Bayles, K.W. A Central Role for Carbon-Overflow Pathways in the Modulation of Bacterial Cell Death. PLoS Pathog. 10(6): e1004205, 2014.

Thomas, V.C., Kinkead, L.C., Janssen, A., Schaeffer, C.A., Woods, K.M., Lindgren, J.K., Peaster, K.M., Chaudhari, S.S., Sadykov, M., Jones, J., Mohamadi Abdel Ghani, S.M., Zimmerman, M.C., Bayles, K.W., Somerville, G.A., and Fey, P.D. A dysfunctional TCA cycle enhances fitness of Staphylococcus epidermidis during β-lactam stress. (2013) mBio 4(4): e00437-13, 2013.

Sadykov, M.R., Thomas, V.C., Marshall, D.D., Wenstrom, C.J., Moormeier, D.E., Widhelm, T.J., Nuxoll, A.S., Powers, R., and Bayles, K.W. Inactivation of the Pta-AckA pathway causes cell death in Staphylococcus aureus. J. Bacteriol. 195: 3035-3044, 2013.

Moormeier, D.E., Endres, J.L., Mann, E.E., Sadykov, M.R., Horswill, A.R., Rice, K.C., Fey, P.D., and  Bayles, K.W. Use of microfluidic technology to analyze gene expression during Staphylococcus aureus biofilm formation reveals distinct physiological niches. Appl. Environ. Microbiol. 79: 3413-3424, 2013.

Nuxoll, A.S., Halouska, S.M., Sadykov, M.R., Hanke, M.L., Bayles, K.W., Kielian, T.M., Powers, R., and Fey, P.D. CcpA regulates arginine biosynthesis in Staphylococcus aureus through repression of proline catabolism. PLoS Pathog. 8(11): e1003033, 2012.

Sadykov, M.R., and Bayles, KW. The control of death and lysis in staphylococcal biofilms: a coordination of physiological signals. Curr. Opin. Microbiol. 15: 211-215, 2012.

Sadykov, M.R., Hartmann, T., Mattes, T.A., Hiatt, M., Jann, N.J., Zhu, Y., Ledala, N., Landmann, R., Herrmann, M., Rohde, H., Bischoff, M., and Somerville, G.A. CcpA coordinates central metabolism and biofilm formation in Staphylococcus epidermidis. Microbiology. 157: 3458-3468, 2011.

Zhu, Y., Nandakumar, R., Sadykov, M.R., Madayiputhiya, N., Luong, T.T., Gaupp, R., Lee, C.Y., and Somerville, G.A. RpiR homologues may link Staphylococcus aureus RNAIII synthesis and pentose phosphate pathway regulation. J. Bacteriol. 193: 6187-6196, 2011.

Zhang, B., Halouska, S., Schiaffo, C.E., Sadykov, M.R., Somerville, G.A., and Powers, R. NMR analysis of a stress response metabolic signaling network. J. Proteome Res. 10: 3743-3754, 2011.

Takahashi, N., Ohashi, S., Sadykov, M.R., Mizutani-Ui, Y., and Kobayashi, I. IS-linked movement of a restriction-modification system. PLoS One. 6(1): e16554, 2011.

Sadykov, M.R., Zhang, B., Halouska, S., Nelson, J.L., Kreimer, L.W., Zhu, Y., Powers,R., and  Sommerville, G.A. Using NMR metabolomics to investigate tricarboxylic acid cycle-dependent signal transduction in Staphylococcus epidermidis. J. Biol. Chem. 285: 36616-36624, 2010.

Majerczyk, C.D., Dunman, P.M., Luong, T.T., Lee, C.Y., Sadykov, M.R., Somerville, G.A, Bodi, K., and Sonenshein, A.L. Direct targets of CodY in Staphylococcus aureus. J. Bacteriol. 192: 2861-2877, 2010.

Sadykov, M.R., Mattes, T,A., Luong, T.T., Zhu, Y., Day, S.R., Sifri, C.D., Lee, C.Y., and Somerville, G.A. Tricarboxylic acid cycle-dependent synthesis of Staphylococcus aureus Type 5 and 8 capsular polysaccharides. J. Bacteriol. 192: 1459-1462, 2010.

Zhu, Y., Xiong, Y.Q., Sadykov, M.R., Fey, P.D., Lee, M.G., Lee, C.Y., Bayer, A.S., and Somerville, G.A. Tricarboxylic acid cycle mediated attenuation of Staphylococcus aureus in vivo virulence by selective inhibition of amino acid transport. Infect. Immun. 77: 4256-4264, 2009.

Sadykov, M. R., Olson, M. E., Halouska S., Zhu, Y., Fey, P. D., Powers, R., and Somerville, G. A. Tricarboxylic acid cycle dependent regulation of Staphylococcus epidermidis polysaccharide intercellular adhesin synthesis. J. Bacteriol. 190: 7621-7632, 2008.

Majerczyk, C.D., Sadykov, M.R., Luong, T.T., Lee C., Somerville, G.A. and Sonenshein, A.L. Staphylococcus aureus CodY negatively regulates virulence gene expression. J. Bacteriol. 190: 2257-2265, 2008.

Sadykov, M., Asami, Y., Niki, H., Handa, N., Itaya, M., Tanokura, M. and Kobayashi, I. Multiplication of a restriction modification gene complex. Mol. Microbiol. 48: 417-427, 2003.

Handa, N., Nakayama, M., Sadykov, M. and Kobayashi, I. Experimental genome evolution: large-scale genome rearrangements associated with resistance to replacement of a chromosomal restriction-modification gene complex. Mol. Microbiol. 40: 932-940, 2001.

For a detailed list of publications, click here.