Dhananjay D. Shinde, PhD

Department Affiliation
Assistant Professor 

Metabolomics/ Lipidomics

Education and Training
PhD (Chemistry) IICT, CSIR Hyderabad, India 2009
Post-doctoral research fellow, Inje University College of Medicine, Busan, S. Korea 2009-2012
Manager, Albany Molecular Research Inc. (AMRI) 2012-2014
Scientist/In-charge, Mass Spectrometry Facility, Bangalore Life Sciences Cluster Bangalore, India 2014-2019
Postdoctoral research associate, University of Nebraska Medical Center, 2019-2020
Senior Scientist, University of Nebraska Medical Center, 2020-2021

Scientific Memberships
Member of "American Society for Mass Spectrometry" Santa Fe, NM 87505 (USA)
Lifetime member of Indian Society of Mass Spectrometry (ISMAS)

Notable Publications
MUC5AC serves as the nexus for β-catenin/c-Myc interplay to promote glutamine dependency during pancreatic cancer chemoresistance Koelina Ganguly, Rakesh Bhatia, Sanchita Rauth, Andrew Kisling, Pranita Atri, Christopher Thompson, Raghupathy Vengoji, Shiv Ram Krishn, Dhananjay Shinde, Vinai Thomas, Sukhwinder Kaur, Kavita Mallya, Jesse L. Cox, Sushil Kumar, Surinder K. Batra  Gastroenterology, 2021 Sep 14; S0016-5085(21)03496-X. doi: 10.1053/j.gastro.2021.09.017

Accumulation of succinyl-CoA perturbs the MRSA succinylome and is associated with increased susceptibility to beta-lactam antibiotics.  Christopher Campbell, Claire Fingleton, Merve Zeden, Emilio Bueno, Laura Gallagher, Dhananjay Shinde, Jong-Sam Ahn, Heather Olson, Thomas Fillmore, Joshua Adkins, Fareha Razvi, Kenneth Bayles, Paul Fey, Vinai Thomas, Felipe Cava, Geremy Clair, and James O'Gara, mBio (In Press, May 2021).

A critical role for staphylococcal nitric oxide synthase in controlling flavohemoglobin toxicity, Communicated.

Metabolome profiling reveals impact of water limitation on grain filling in contrasting rice genotypes.
P Vijayaraghavareddy, NN Akula, VS Ramu, RGH Math, DD Shinde, Plant Physiology and Biochemistry (In Press; 2021).

Design and Synthesis of New Tubulin Polymerization Inhibitors Inspired from Combretastatin A‐4: An Anticancer Agent.  A Sharma, D Talimarada, UP Yadav, N Singh, AS Reddy, D Bag, DD Shinde ... Chemistry Select 5 (37), 11560-11572.

LC-HRMS based approach to identify novel sphingolipid biomarkers in breast cancer patients.
P Bhadwal, D Dahiya, Dhananjay Shinde, K Vaiphei, RGH Math, V Randhawa & N Agnihotri, Scientific Reports 10, 4668, 2020.

A novel mass assay to measure phosphatidylinositol-5-phosphate from cells and tissues.  A Ghosh, S Sharma, Dhananjay Shinde, V Ramya, P Raghu, Bioscience Reports 39 (10) BSR20192502, 2019.

Phosphatidylinositol 5 Phosphate 4-Kinase Regulates Plasma-Membrane PIP3 Turnover and Insulin Signaling. S Sharma, S Mathre, V Ramya, Dhananjay Shinde, P Raghu, Cell Reports 27 (7), 1979-1990. e7, 2019

Signalling Growth through Lipid Kinases. S Sharma, S Mathre, V Ramya, Dhananjay Shinde, P Raghu, Biophysical Journal 116 (3), 130a, 2019

Functional analysis of mammalian phospholipase D enzymes. A Panda, R Thakur, H Krishnan, A Naik, Dhananjay Shinde, P Raghu, Bioscience Reports 38 (6), BSR20181690, 2018

For a detailed list of publications, click here.