Rakesh K. Singh, Ph.D.

Department Affiliations
Professor
Vice Chair, Graduate Education
Director, Department of Pathology and Microbiology Graduate Program

Interests
Tumor Growth and Metastasis, Angiogenesis, Tumor Immunology, Cytokine Biology

Education
Postdoctoral Fellow, M.D. Anderson Cancer Center, Houston, TX, 1994
Ph.D., Banaras Hindu University, Varanasi, India, 1991
M.Sc., Banaras Hindu University, Varanasi, India, 1987
B.Sc. (Hons.), Banaras Hindu University, Varasani, India, 1985

National Activities
Editorial Board Member: American Journal of Cancer Research; The Open System Biology Journal; The Open Circulation & Vascular Journal; The Open Breast Cancer Journal; Clinical Research and Regulatory Affairs; Frontiers in Biosciences   
National and International Grant Review Committee: Department of Defense Breast Cancer Research Program Grant review committee (Breast Cancer Peer Review Panel PBY1 and PBY-5); Cancer Research, UK, Project Grant Application Review Committee; Susan G. Komen Breast Cancer Foundation, Targeted Therapeutics-2 (TT-2) Grant Review Committee; European Research Council LS2 Review panel (Genetics, Genomics, Bioinformatics and Systems biology); Department of Defense Prostate Cancer Research Program Grant review committee (Peer Review Panel PBY-2); Medical Research Council, UK, Project Grant Application Review Committee; Biomedical Research Council, Grant application Review, Singapore; National Institutes of Health.

Notable Publications
Sharma B, Nannuru KC, Varney ML, Singh RK.  Host CXCR2 influences tumor growth and metastasis by limiting proliferation, angiogenesis, immune infiltration and enhancing apoptosis in mammary tumors.  Clinical and Experimental Metastasis, 32:65-72, 2015. PubMed PMID 25511644.

Varney ML, and Singh RK. VEGF-C-VEGFR3/Flt4 axis regulates mammary tumor cell proliferation, growth and metastasis in an autocrine manner. American J. Cancer Research, 15:616-628, 2015. PMID: 25973301.

Sharma B, Varney ML, Saxena S, Wu L, and Singh RK.  Induction of CXCR2 ligands, stem cell-like phenotype, and metastasis in chemotherapy-resistant breast cancer cells. Cancer Letters, 372: 192-200, 2016. PMID: 2679746

Purohit A, Varney ML, Rachagani S, Ouellette M, Batra SK, Singh RK.  CXCR2 signaling regulates KRAS(G12D)-induced autocrine growth of pancreatic cancer. Oncotargets, 2016, doi: 10.18632/oncotarget.6906. [Epub ahead of print] PMID: 26771140

Hassan HM, Varney ML, Chaturvedi NK, Joshi SS, Weisenburger DD, Singh RK, Dave BJ. Diclofenac induces apoptosis and suppresses mantle cell lymphoma proliferation independent of p53 status. Leukemia & Lymphoma, 13: 1-16, 2016. PMID:278074052

Wen D, Peng Y, Lin F, Singh RK, Mahato RI. Rubone as a miR-34a modulator for treating Paclitaxel resistant prostate cancer. Cancer Research, 77: 3244-3254, 2017.  PMID: 28428276.

Wu S, Saxena S, Wu L, Varney ML, and Singh RK. CXCR1/2 chemokine network regulates melanoma resistance to chemotherapies mediated by NF-kB. Current Molecular Medicine, 2017; DOI: 10.2174/1566524018666171219100158; PMID: 29256349

Saxena S, Hayashi Y, Wu L, Awaji M, Atri P, Varney ML, Purohit A, Rachagani S, Batra SK, and Singh RK. Pathological and functional significance of Semaphorin5A in pancreatic cancer progression and metastasis. Oncotagets, 9:5931-5943, 2017; doi.org/10.18632/ oncotarget.23644. PMID: 29464045; PMCID: PMC5814185

Roy S, Bag A, Dutta S, Polavaram NS, Islam R, Schellenburg S, Banwait J, Guda C, Ran S, Hollingsworth M, Singh RK, Talmadge JE, Muders MH, Batra SK, and Datta K. A novel tumor-promoting function of Neuropilin-2 in macrophages. Cancer Res. 78:5600-5617, 2018. PubMed PMID: 30111533; PMCID: PMC6168405

Saxena S, Purohit A, Varney ML, Hayashi Y, and Singh RK. Semaphorin-5A Maintains Epithelial Phenotype of Malignant Pancreatic Cancer Cells. BMC Cancer, 18:1283-1297, 2018, PMID: 30577767 PMCID: PMC6303891 DOI: 10.1186/s12885-018-5204-x

Awaji M and Singh RK. Cancer-associated fibroblasts functional heterogeneity in pancreatic ductal adenocarcinoma. Cancers, 11(3):290-204, 2019. doi:10.3390/cancers11030290

For a detailed list of publications, click here.