Rakesh K. Singh, Ph.D.

Department Affiliations
Professor
Vice Chair, Graduate Education
Director, Department of Pathology and Microbiology Graduate Program

Interests
Tumor Growth and Metastasis, Angiogenesis, Tumor Immunology, Cytokine Biology
Please see Dr. Singh's laboratory webpage.
 
National Activities
Editorial Board Member: American Journal of Cancer Research; The Open System Biology Journal; The Open Circulation & Vascular Journal; The Open Breast Cancer Journal; Clinical Research and Regulatory Affairs; Frontiers in Biosciences   
National and International Grant Review Committee: Department of Defense Breast Cancer Research Program Grant review committee (Breast Cancer Peer Review Panel PBY1 and PBY-5); Cancer Research, UK, Project Grant Application Review Committee; Susan G. Komen Breast Cancer Foundation, Targeted Therapeutics-2 (TT-2) Grant Review Committee; European Research Council LS2 Review panel (Genetics, Genomics, Bioinformatics and Systems biology); Department of Defense Prostate Cancer Research Program Grant review committee (Peer Review Panel PBY-2); Medical Research Council, UK, Project Grant Application Review Committee; Biomedical Research Council, Grant application Review, Singapore; National Institutes of Health.

Recent Publications
Varney ML, and Singh RK. VEGF-C-VEGFR3/Flt4 axis regulates mammary tumor cell proliferation, growth and metastasis in an autocrine manner. American J. Cancer Research, 15:616-628, 2015.

Sharma B, Nannuru KC, Varney ML, Singh RK.  Host CXCR2 influences tumor growth and metastasis by limiting proliferation, angiogenesis, immune infiltration and enhancing apoptosis in mammary tumors.  Clinical and Experimental Metastasis, 32:65-72, 2015. PubMed PMID 25511644.

Purohit A, Sadanandam A and Singh RK. Semaphorins in tumor growth, angiogenesis and metastases” Biochim Biophys Acta. 1846:485-493; 2014. PubMed PMID 25263940

Hassan HM, Dave BJ, and Singh RK. TP73, an under-appreciated player in non-Hodgkin lymphoma pathogenesis and management. Current Molecular Medicine,14:1-9, 2014. PubMed PMID:24730526

Hassan HM, Varney, ML, Jain S, Joshi SS, Singh RK and Dave BJ “Disruption of chromosomal locus 1p36 differentially modulates TAp73 and DNp73 expression and aggressiveness in Follicular lymphoma. Leuk Lymphoma. 55: 2924-2931, 2014. PubMed PMID: 24660851.

Jami MS, Hou J, Hassan H, Dong J, Liu H, Geng L, Wang JJ, Li Y, Singh RK and Ding SJ.  Functional Proteomic Analysis Reveals KIAA1199 as a Novel Regulator of Breast Tumor Growth, Angiogenesis and Invasiveness. BMC Cancer. 14:194, 2014. doi: 10.1186/1471-2407-14-194. PubMed PMID: 24628760.

Sharma B, Nawandar D, Varney, ML, Nannuru KC, Singh RK. Targeting CXCR2 enhances chemotherapeutic response, inhibits mammary tumor growth, angiogenesis and lung metastasis. Mol Cancer Ther. 12:799-808, 2013. doi: 10.1158/1535-7163.MCT-12-0529. Epub 2013 Mar 6. PubMed PMID: 23468530; PubMed Central PMCID: PMC3653628.

Futakuchi M, and Singh RK.  Animal models for mammary tumor growth in the bone microenvironment.  Breast Cancer, 20:195-203, 2013 doi: 10.1007/s12282-013-0439-5. Epub 2013 Jan 19. Review. PubMed PMID: 23335063

Wu S, Singh S, Varney ML, Kindle S, and Singh RK.  Modulation of CXCL-8 expression in human melanoma cells regulates tumor growth, angiogenesis, invasion and metastasis.  Cancer Medicine,1:306-317, 2012.  doi: 10.1002/cam4.28

Sadanandam A, Sidhu SS, Wullschlegar S, Singh S, Varney ML, Yang CS, Ashour, AK, Batra SK, and Singh RK. Soluble Semaphorin 5A mediates Reduced Pancreatic Tumor Burden but Enhanced Micrometastasis and Increased Endothelial Cell Proliferation. British J. Cancer, 107:501-507, 2012. PMID:22782341.

For a detailed list of publications, click here.