Department Affiliations
Professor
Bhavana Janakbhai Dave Distinguished Professor (2024)
Director, Warren G. Sanger Human Genetics Laboratory
Interests
Genomic characterization of hematologic malignancies, lung cancer and breast cancer; application of modern genomic techniques in clinical laboratory diagnosis; exploring the best interpretation for unusual findings and improvement of laboratory genetic/genomic testing.
Education
MD (MBBS), Tongji Medical University, Wuhan, China, 1989
MS, Tongji Medical University/Tongji Hospital, Wuhan, China, 1995
PhD, Albert-Ludwigs University, Freiburg, Germany, 1998
Postgraduate Training
Clinical Training and Clinical Practice, Internal Medicine/Infectious Diseases, Tongji Hospital, Tongji Medical University, Wuhan, Hubei, China, 1989-1996
Clinical Fellowship, Clinical Cytogenetics and Genomics, Institute of Genomic Medicine, Rutgers New Jersey Medical School (previously UMDNJ), Newark, NJ, 2009-2011Clinical Fellowship, Clinical Molecular Genetics and Genomics, Institute of Genomic Medicine, Rutgers New Jersey Medical School (previously UMDNJ), Newark, NJ, 2011-2013
Board Certification
American Board of Medical Genetics and Genomics, 2013
Notable Publications
Wang L, Wang W, Beird HC, Cheng X, Fang H, Tang G, Toruner GA, Yin CC, You MJ, Issa GC, Borthakur G, Peng G, Khoury JD, Medeiros LJ, Tang Z. PPP1R7 Is a Novel Translocation Partner of CBFB via t(2;16)(q37;q22) in Acute Myeloid Leukemia. Genes (Basel). 2022 Jul 29;13(8):1367. doi: 10.3390/genes13081367. PMID: 36011278; PMCID: PMC9407081.
Zhao M, Medeiros LJ, Wang W, Tang G, Jung HS, Sfamenos SM, Fang H, Toruner GA, Hu S, Yin CC, Lin P, Gu J, Peng G, You MJ, Khoury JD, Wang SA, Tang Z. Newly designed breakapart FISH probe helps to identify cases with true MECOM rearrangement in myeloid malignancies. Cancer Genet. 2022 Apr;262-263:23-29. doi: 10.1016/j.cancergen.2021.12.009. Epub 2021 Dec 23. PMID: 34974290.
Fang H, Beird HC, Wang SA, Ibrahim AF, Tang Z, Tang G, You MJ, Hu S, Xu J, Li S, Yin CC, El Hussein S, Le N, Futreal PA, Bueso-Ramos C, Thakral B, Kadia TM, Thornton R, Little L, Gumbs C, Song X, Medeiros LJ, Wang W. T-prolymphocytic leukemia: TCL1 or MTCP1 rearrangement is not mandatory to establish diagnosis. Leukemia. 2023 Sep;37(9):1919-1921. doi: 10.1038/s41375-023-01956-3. Epub 2023 Jul 13. PMID: 37443196.
Tashakori M, Kadia T, Loghavi S, Daver N, Kanagal-Shamanna R, Pierce S, Sui D, Wei P, Khodakarami F, Tang Z, Routbort M, Bivins CA, Jabbour EJ, Medeiros LJ, Bhalla K, Kantarjian HM, Ravandi F, Khoury JD. TP53 copy number and protein expression inform mutation status across risk categories in acute myeloid leukemia. Blood. 2022 Jul 7;140(1):58-72. doi: 10.1182/blood.2021013983. PMID: 35390143; PMCID: PMC9346958.
Yang H, Garcia-Manero G, Sasaki K, Montalban-Bravo G, Tang Z, Wei Y, Kadia T, Chien K, Rush D, Nguyen H, Kalia A, Nimmakayalu M, Bueso-Ramos C, Kantarjian H, Medeiros LJ, Luthra R, Kanagal-Shamanna R. High-resolution structural variant profiling of myelodysplastic syndromes by optical genome mapping uncovers cryptic aberrations of prognostic and therapeutic significance. Leukemia. 2022 Sep;36(9):2306-2316. doi: 10.1038/s41375-022-01652-8. Epub 2022 Aug 1. PMID: 35915143; PMCID: PMC9417987.
Tang Z, Wang W, Yang S, El Achi H, Fang H, Nahmod KA, Toruner GA, Xu J, Thakral B, Ayoub E, Issa GC, Yin CC, You MJ, Miranda RN, Khoury JD, Medeiros LJ, Tang G. 3q26.2/MECOM Rearrangements by Pericentric Inv(3): Diagnostic Challenges and Clinicopathologic Features. Cancers (Basel). 2023 Jan 11;15(2):458. doi: 10.3390/cancers15020458. PMID: 36672407; PMCID: PMC9856433.
Issa GC, Zarka J, Sasaki K, Qiao W, Pak D, Ning J, Short NJ, Haddad F, Tang Z, Patel KP, Cuglievan B, Daver N, DiNardo CD, Jabbour E, Kadia T, Borthakur G, Garcia-Manero G, Konopleva M, Andreeff M, Kantarjian HM, Ravandi F. Predictors of outcomes in adults with acute myeloid leukemia and KMT2A rearrangements. Blood Cancer J. 2021 Sep 29;11(9):162. doi: 10.1038/s41408-021-00557-6. PMID: 34588432; PMCID: PMC8481264.
Tang Z, Chen H, Hong L, Tang G, Toruner GA, Wang W, Roy Chowdhuri S, Yin W, Jung HS, Gu J, Routbort MJ, Zhang J, Khoury JD, Medeiros LJ. Inconsistent Intersample ALK FISH Results in Patients with Lung Cancer: Analysis of Potential Causes. Cancers (Basel). 2020 Jul 14;12(7):1903. doi: 10.3390/cancers12071903. PMID: 32674491; PMCID: PMC7409019.
Tang Z, Toruner GA, Tang G, Yin CC, Wang W, Hu S, Thakral B, Wang SA, Miranda RN, Khoury JD, Medeiros LJ. Chronic myeloid leukemia with insertion-derived BCR-ABL1 fusion: redefining complex chromosomal abnormalities by correlation of FISH and karyotype predicts prognosis. Mod Pathol. 2020 Oct;33(10):2088. doi: 10.1038/s41379-020-0632-y. PMID: 32737448.
Tang Z, Zhang J, Lu X, Wang W, Chen H, Robinson MK, Cheng J, Tang G, Medeiros LJ. Coexistent genetic alterations involving ALK, RET, ROS1 or MET in 15 cases of lung adenocarcinoma. Mod Pathol. 2018 Feb;31(2):307-312. doi: 10.1038/modpathol.2017.109. Epub 2017 Sep 15. PMID: 28914263.
For a detailed list of publications click here.