Jian Xie, PhD

Department Affiliations
Assistant Professor

My research interests center on understanding membrane-associated virus-host interactions in infection and innate immunity.

Education and Training
BSc, Department of Virology, College of Life Science, Wuhan University, China, 1997
MSc, Department of Microbiology, College of Life Science, Wuhan University, China, 2001
PhD, Biochemistry and Biophysics Graduate Program, Rensselaer Polytechnic Institute, Troy, New York, 2015
Postdoctoral Associate, Yale School of Medicine and Yale Cancer Center, Yale University, New Haven, CT, 2020
Associate Research Scientist, Yale School of Medicine and Yale Cancer Center, Yale University, New Haven, CT, 2022

National Activities
Member, American Society for Virology
Member, American Association for the Advance of Science
Member, American Chemical Society

Academic Service
Guest Editor, Pathogens, Special Issue "Membrane-Associated Virus-Host Interaction in Infetion and Innate Immunity", 2022-Present
Editorial Board Member: Pathology and Laboratory Medicine, 2022-Present
Guest Editor: JoVE, section of "the Human Papillomavirus Entry mechanism", 2020 - Present 
Referee: Viruses, Vaccines, Viorlogy Journal, Journal of Theorectical Biology, ACS publications, 2015-Present

Jian Xie, Daniel DiMaio. Inhibitors of Cellular Deubiquitinases as Anti-Viral Agents, Applying through Yale Ventures.

Notable Publications
Xie J, Zhang P, Crite M, Lindsay C, DiMaio D. Retromer Stabilizes Transient Membrane Insertion of L2 Capsid Protein during Retrograde HPV entry. Sci. Adv., 2021, 7: eabh4276.

Jian Xie, Daniel DiMaio. Traptamer Screening: A New Functional Genomics Approach to Study Virus Entry and Other Cellular Processes. FEBS J., 2021, DOI: 10.1111/febs.15775.

Xie J, Heim E, Crite M, DiMaio E. TBC1D5-Catalyzed Cycling of Rab7 is Required for Retromer-Mediated Human Papillomavirus Trafficking during Virus Entry. Cell Rep., 2020, 31: 107750.

Xie J, Zhang P, Crite M, DiMaio D. Papillomaviruses Go Retro. Pathogens, 2020, 9, 267.

Zhao J, Ciulla D, Xie J, et al.  General Base Swap Preserves Activity and Expands Substrate Tolerance in Hedeghog Autoprocessing. J. Am. Chem. Soc., 2019, 141: 18380-18384.

Xie J, Owen T, Xia K, Callahan B, Wang C. A Single Aspartate Coordinates Two Catalytic Steps in Hedgehog Autoprocessing. J. Am. Chem. Soc., 2016, 138: 10806-10809.

Xie J, Owen T, Xia K, Singh AV, et al. Zinc Inhibits Hedgehog Autoprocessing: Linking Zinc Deficiency with Hedgehog Activation. J. Biol. Chem., 2015, 290:11591-11600. (One of the top five most viewed articles in JBC website between March and April 2015)

Chen W, Gamache E, Rosenman D, Xie J, Lopez M, Li Y, Wang C. Familiar Alzheimer’s Mutations within APPTM increase Aβ42 Production by Enhancing Accessibility of ε-Cleavage site. Nature Communications, 2014, 5: 3037.

Xie J, Du Z, Callahan B, Belfort M, Wang C. 1H, 13C, and 15N NMR Assignments of a Drosophila Hedgehog Autoprocessing Domain. Biomol NMR Assign, 2014, 8: 279-281.

Xie J†, Zhang P†, Li C, Huang Q, Zhou R, Peng T. Mechanistic Insights into the Roles of Three Linked Single-Stranded Template Binding Residues of MMLV Reverse Transcriptase in Misincorporation and Mispair Extension Fidelity of DNA Synthesis., 2011, 479: 47-56.

† These authors contributed equally to this work.