Laboratory of Suvendra Bhattacharyya, MSc, PhD
Research Goals
Epigenetic regulation in neurodegenerative processes is what we are exploring. Through our research we are working to decipher the mechanism of how the epigenetic regulators (i.e., miRNAs) may get exported from glial cells to neuronal cells to contribute to the sustenance and viability of neurons. How this cross-communication process via miRNA exchange may affect the neuronal signaling and memory formation is another research question we are following. We also like to see how the extracellular vesicles (EVs) derived from glial cells control the axonal cargo trafficking process to control neuronal activity in normal and disease/aging brain. We are using mouse primary neurons and glial cells to explore the mechanistic detail and will explore mouse models to validate our findings.
Techniques used in laboratory
- Epigenetic regulation in neurodegenerative diseases
- Extracellular Vesicles
- miRNA-mediated gene repression
- Translation Control in neurodegenerative diseases
- Intercellular communications of non-coding RNAs
Collaborators
Margaret R. Larson Professor of Internal Medicine and Infectious Diseases
Chair, Department of Pharmacology and Experimental Neuroscience
Assistant Professor
Funding
Role: PI
Source: BR/IN/Swiss/53/SNB/2018-2019 (PI: Bhattacharyya) 03/19/2019 - 03/18/2023
This grant investigates the elucidation of the interplay of cell autonomous and pathogen- derived factors on the susceptibility of individual host cells to infection by a protozoan pathogen.
Role: PI
Source: CEFIPRA (PI: Bhattacharyya) 11/10/2019-10/31/2022 (6003-J)
Indo French Research Grant $USD 50,000
The goal of this project is to study the Mechanism of P-body targeting of mRNAs in mammalian cells.
Role: PI
Source: High Risk High Reward (PI: Bhattacharyya) 03/28/2017 - 03/27/2020
DST/HRR/2016/000093 $USD 800,000
This is a Compartmentalization of microRNA-Dependent Posttranscriptional Processes in Mammalian Cells : Role of Subcellular Structures and Organelles.
Role: PI
Source: Swarnajayanti Fellowship (PI: Bhattacharyya) 04/01/2016 -03/31/2021
DST/SJF/LSA-03/2014-15S $USD 400,000
This proposal will determine the role of inter- and subcellular miRNA trafficking in controlling lipid metabolism in mammalian liver cells.
Role: PI
Source: Wellcome Trust UK (084324/Z/07/A) (PI: Bhattacharyya) 01/01/2009-11/31/2014
International Senior Research Fellowship $USD 1,000,000
This proposal will determine the Mechanism of P-body targeting of miRNAs in mammalian cells.
Role: PI
Source: HFSP CDA Grant (2007-3) (PI: Bhattacharyya) 04/01/2008 -03/31/2012
$USD 300,000
This proposal will determine the effect of cell microenvironment on miRNAs activity.