Samuel M. Cohen, M.D., Ph.D.

Department Affiliations
Professor
Havlik-Wall Professor of Oncology (1985)

Interests
Chemical Carcinogenesis, Toxicology and Risk Assessment, Surgical Pathology, Urologic Pathology
For full details of Dr. Cohen's research, please visit his lab's webpage.

Education and Training
B.S. (Honors) University of Wisconsin, 1967
M.D., Ph.D. (Experimental Oncology) University of Wisconsin, 1972
Residency, St. Vincent Hospital, Worcester, MA, 1972-1975
Board Certified in Anatomic and Clinical Pathology, 1976

Teaching Activities
Medical Students: Small group discussions and laboratories
Graduate students: Advisor, supervisory committees
Residents: Surgical pathology, conferences

National Activities
Editorial Board or Associate Editor:
Fd. Chem. Toxicol., Toxicol. Pathol. Crit. Rev. Toxicol., Toxicology, Reg. Toxicol. Pharmicol, Int. J. Oncology, Urologic Oncology, Toxicol. Pathol., Pathol. Intl., Crit. Rev. Toxicol., Toxicology, J. Toxicol.
Advisory Panels:
Int. Life Sci. Inst. (ILSI) - Health and Environmental Sciences Institute Board of Trustees (HESI), 2001-present; Chairman, 2006-2008
International Life Sciences Institute Board of Trustees, 2007- 2016, Vice Chairman, 2010-2012. Chairman, 2012-2015
WHO-IPCS; Expert Panel on Carcinogens, 1999-2006
Expert Panel of the Flavors and Extracts Manufacturers Association, 2002-present
Numerous committees & panels with NIH, EPA, FDA, WHO, IARC, IPCS, national and international scientific organizations.
Academy of Toxicological Sciences, fellow 1995-present (Board of Directors 2014-present)

Notable Publications
Cohen, S.M.
, Arnold, L.L., Beck, B.D., Lewis, A.S., and Eldan, M. Evaluation of the carcinogenicity of inorganic arsenic. Crit. Rev. Toxicol., 43:711-752, 2013. (PMID: 24040994)

Dodmane, P.R., Arnold, L.L., Pennington, K.L., and Cohen, S.M. Orally administered nicotine induces urothelial hyperplasia in rats and mice. Toxicology, 315:49-54, 2014. (PMID: 24269753)

DaRocha, M.S., Arnold, L.L., De Oliveira, M.L.C.S., Ihlasch, S.M., Cardoso, A.P.F., Pontes, M.G.N., Dodmane, P.R., Cohen, S.M., and de Camargo, J.L.V. Diuron-induced rat urinary bladder carcinogenesis: mode of action and human relevance evaluation using the International Programme on Chemical Safety framework. Crit. Rev. Toxicol., 44: 393-406, 2014. (PMID: 24512549)

Embry, M.R., Bachman, A., Bell, D., Boobis, A., Cohen, S.M., Dellarco, M., Dewhurst, I., Doerrer, N., Hines, R., Moretto, A., Pastoor, T., Phillips, R., Rowlands, J.C., Tanir, J.Y., Wolf, D., and Doe, J. Risk assessment in the 21st century (Risk21): Roadmap and matrix. Crit. Rev. Toxicol., 44(S3): 6-16, 2014. (PMID: 25070414)

Yamada, T., Cohen, S.M., and Lake, B.G. The mode of action for phenobarbital-induced rodent liver tumor formation is not relevant for humans: recent studies with humanized mice. Toxicol. Sci., 147:298-299, 2015. (PMID: 26408565)

Strupp, C., Bomann, W., Cohen, S.M., and Weber, K. Relationship of metabolism and cell proliferation to the mode of action of fluensulfone-induced mouse lung tumors. II: Additional mechanistic studies. Toxicol. Sci., 154: 296-308, 2016. (PMID: 27605420)

Boobis, A.R., Cohen, S.M., Dellarco, V.L., Doe, J.E., Fenner-Crisp, P.A., Moretto, A., Pastoor, T.P., Schoeny, R.S., Seed, J.G., and Wolf, D.C. Classification schemes for carcinogenicity based on hazard-identification have become outmoded and serve neither science nor society. Reg. Toxicol. Pharmacol, 82: 158-166, 2016. (PMID: 27780763)

Cohen, S.M. The relevance of experimental carcinogenicity studies to human safety. Curr. Opin. Toxicol., 3: 6-11, 2017.

Cohen, S.M., Eisenbrand, G., Fukushima, S., Gooderham, N.J., Guengerich, F.P., Hecht, S.S., Rietjens, I.M.C.M., Davidsen, J.M., Harman, C.L., and Taylor, S.V. Updated procedure for the safety evaluation of natural flavor complexes used as ingredients in food. Food Chem. Toxicol., 113: 171-178, 2018. (PMID: 29355624) DOI: 10.1016/j.jconrel.2017.08.038

Cohen, S.M. Screening for human urinary bladder carcinogens: Two-year bioassay is unnecessary. Toxicol. Res., 7: 565-575, 2018. (PMID: 30090607) DOI: 10.1039/C7TX00294G.

For a detailed list of publications, click here.