Javeed Iqbal, Ph.D.

Department Affiliations
Associate Professor

Interests
Genomic signatures of non-Hodgkin’s lymphomas to elucidate:
      1.  Molecular Pathogenesis and Target Characterization
      2.  Molecular Diagnosis and Target Discovery
      3.  Oncogenic Pathway identification for the novel Clinical Investigations

Education
B.Sc. (Hons) &  M.Sc., Biochemistry; A.M.U., Aligarh, India
Ph.D., Hans Knöll institute, Friedrich-Schiller-Universität, Jena, Germany
M.S., Clinical and Translational Research; University of Nebraska Medical Center (UNMC), Omaha, NE
Postdoctoral Fellowship, Pathology and Microbiology, UNMC, Omaha, NE

Research training
Institute of Genomics and Integrative Biology (IGIB) New Delhi-India
Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), Bangalore, India;

Notable Publications
Wang C, McKeithan TW, Gong Q, Zhang W, Bouska A, Gascoyne RD, Wu X, Wang J, Muhammad Z, Jiang B, Rohr J, Cannon A, Steidl C, Fu K, Li Y, Hung S, Weisenburger DD, Greiner TC, Smith L, Ott G, Rogan EG, Staudt LM, Vose J, Iqbal J#, Chan WC#. IDH2R172 mutations define a unique subgroup of patients in angioimmunoblastic T-cell lymphoma. Blood, 126(15):1741-1752, 2015. PMCID: PMC4600014

Rohr JM, Guo S, Huo J, Bouska A, Lachel C, Li Y, Simone P, Zhang W, Gong Q, Wang C, Cannon A, Rosenwald A, Gascoyne R, Fu K, Greiner T, Weisenburger D, Vose JM, Staudt LM, Xiao W, Borgstahl GEO, Davis S, McKeithan TW, Iqbal J#, Chan W#.  Recurrent activating mutations of CD28 in peripheral T-cell lymphomas. Leukemia, 2015. PMID: 26719098

Iqbal J#, Shen Y, Huang X, Wake L, Liu Y, Liu C, Deffenbacher K, Lachel CM, Wang C, Rohr J, Smith LM, Bagavati S, Dybkaer K, Greiner TC,. Vose JM, Jaffe E, Rimsza L, Rosenwald A, Ott G,  Delabie J, Campo E, Braziel RM, Cook JR, Tubbs RR, Armitage JO, Weisenburger DD, McKeithan TW, Gascoyne RD, Staudt  LM, Chan WC. Global microRNA expression profiling uncovers molecular markers for classification and prognosis for aggressive B-cell lymphomas. Blood, 125(7):1137-1145, 2015. PMCID: PMC4326773

Iqbal J#, Wright G, Wang C, Andreas R, Gascoyne RD., Weisenburger DD, Greiner TC, Smith L, Guo S, Wilcox RA, Teh B, Thye SL, Tan SY, Rimsza LM, Jaffe ES, Campo E, Martinez A, Delabie J. Braziel RM, Cook JR., Tubbs RR., Ott G, Geissinger E,  Gaulard P, Piccaluga PP, Pileri SA, Au WY, Shigeo N, Seto M, Berger F, de Leva L, Connors JM., Armitage J, Vose J, Chan W C, Staudt LM. Gene expression signatures delineate biologic and prognostic subgroups in peripheral T-cell lymphoma. Blood, 123(19):2915-2923, 2014. PMCID: PMC4014836

Liu C#, Iqbal J#, Teruya-Feldstein J, Shen Y, Dabrowska JM, Dybkaer K, Lim MS, Piva R, Barreca A, Pellegrino E, Spaccarotella E, Lachel MC, Kucuk C, Jiang C, Hu X, Bhagvati S, Greiner TC, Weisenburger DD, Aoun P, Perkins SL, Mckeithan TW, Inghirami G, Chan WC. MicroRNA expression profiling identifies molecular diagnostic signatures for anaplastic large cell lymphoma. Blood, 122(12):2083-2092, 2013. (#equal contribution) PMCID: PMC3778551

Huang X, Meng B, Iqbal J, Ding B, Perry AM, Cao W, Smith LM, Bi C, Jiang C, Greiner TC, Weisenburger DD, Rimsza L, Rosenwald A, Ott G, Delabie J, Campo E, Braziel R, Gascoyne R, Cook J, Tubbs R, Jaffe E, Armitage J, Vose J, Staudt L, McKeithan TW, Chan CC, Ye H, and Fu K. Activation of the STAT3 signaling pathway is associated with poor survival in diffuse large B-cell lymphoma patients treated with R-CHOP. J Clin Oncol., 31(36):4520-4528, 2013. PMCID: PMC3871513

Cairns RA#, Iqbal  J#, Lemonnier F, Kucuk C, de Leval L, Jais JP, Parrens M, Martin A, Xerri L, Brousset P, Chan LC, Chan WC, Gaulard P, Mak TW. IDH2 mutations are frequent in angioimmunoblastic T-cell lymphoma. Blood, 119(8):1901-1903, 2012. (#equal contribution) PMCID: PMC3293643

Deffenbacher KE#, Iqbal J#, Sanger W, Shen Y, Lachel C, Liu Z, Liu Y, Lim MS, Perkins SL, Fu K, Smith L, Lynch J, Staudt LM, Rimsza LM, Jaffe E, Rosenwald A, Ott GK, Delabie J, Campo E, Gascoyne RD, Cairo MS, Weisenburger DD, Greiner TC, Gross TG, Chan WC. Molecular distinctions between pediatric and adult mature B-cell non-Hodgkin lymphomas identified through genomic profiling. Blood, 119(16):3757-3766, 2012. (#equal contribution) PMCID: PMC3335381

Iqbal J, Shen Y, Liu Y, Fu K, Jaffe ES, Liu C, Liu Z, Lachel CM, Deffenbacher K, Greiner TC, Vose JM, Bhagavathi S, Staudt LM, Rimsza L, Rosenwald A, Ott G, Delabie J, Campo E, Braziel RM, Cook JR, Tubbs RR, Gascoyne RD, Armitage JO, Weisenburger DD, McKeithan TW, Chan WC. Genome-wide MicroRNA profiling of mantle cell lymphoma reveal a distinct subgroup with poor prognosis. Blood, 119(21):4939-4948, 2012. PMCID: PMC3367895

Iqbal J, Meyer PN, Smith L, Johnson NA, Vose JM, Greiner TC, Connors J, Staudt LM, Rimsza LM, Jaffe E, Rosenwald A, Ott G, Delabie J, Campo E, Braziel RM, Cook J, Tubbs RR, Gascoyne RD, Armitage JO, Weisenburger DD, Chan W. BCL2 Predicts Survival in Germinal Center B-cell-like Diffuse Large B-Cell Lymphoma Treated with CHOP-like therapy and Rituximab. Clin Cancer Res., 17:7785-7795, 2011. PMID: 21933893

Küçük C, Iqbal J, Hu X, Gaulard P, Leval Ld, Srivastava G, Au WY, McKeithan T, Chan WC. PRDM1 is a Tumor Suppressor Gene in Natural Killer Cell Malignancies. Proc Natl Acad Sci., 108:20119-20124, 2011. PMCID: PMC3250125

Iqbal J, Weisenburger DD, Chowdhury A, Tsai MY, Srivastava G, Greiner TC, Kucuk C, Deffenbacher K, Vose J, Smith L, Au WY, Nakamura S, Seto M, Delabie J, Berger F, Loong F, Ko YH, Sng I, Liu X, Loughran TP, Armitage J, Chan WC. Natural killer cell lymphoma shares strikingly similar molecular features with a group of non-hepatosplenic gammadelta T-cell lymphoma and is highly sensitive to a novel aurora kinase A inhibitor in vitro. Leukemia, 25:348-358, 2010. PMID: 21052088

Iqbal J, Weisenburger DD, Greiner TC, Vose JM, McKeithan T, Kucuk C, Geng H, Deffenbacher K, Smith L, Dybkaer K, Nakamura S, Seto M, Delabie J, Berger F, Loong F, Au WY, Ko YH, Sng I, Armitage JO, Chan WC. Molecular signatures to improve diagnosis in peripheral T-cell lymphoma and prognostication in angioimmunoblastic T-cell lymphoma. Blood, 115:1026-1036, 2010. PMCID: PMC2817630

For a detailed list of publications, click here.