Guangshun (Gus) Wang, Ph.D.

Department Affiliations
Associate Professor

Interests
Host defense antimicrobial peptides, Structural bioinformatics, Biomolecular NMR

Please visit Dr. Wang's laboratory webpage for further information on his research.

Education and Training
B.S., Yangzhou University, 1985 (Chemistry)
M.S., Chinese Academy of Sciences, 1988 (Environmental Chemistry)
Ph.D., Simon Fraser University, 1997 (Biophysical Chemistry)
Postdoctoral fellow: Florida State University, 1997-1999 (Structural Biology);
National Institutes of Health, 1999-2002 (Protein NMR)

Notable Publications

Mishra, B., Lushnikova, T., Golla, R.M., Wang, X.Q., Wang, G. 2017. Design and surface immobilization of short anti-biofilm peptides. Acta Biomater. 49, 316-328.

Dong, Y., Lushnikova, T., Golla, R.M., Wang, X.F., Wang, G. 2017. Small molecule mimics of DFTamP1, a database designed anti-Staphylococcal peptide. Bioorg. Med. Chem. 25, 864-869.

Mishra, B., Reiling, S., Zarena, D., Wang, G. 2017. Host defense antimicrobial peptide as antibiotics: design and application strategies. Curr. Opin. Chem. Biol. 38, 87-96.

Wang, G. Li, X., Wang, Z. 2016 APD3: the antimicrobial peptide database as a tool for research and education. Nucleic Acids Research, 44, D1087-D1093.

Mishra, B., Golla, R., Lau, K., Lushnikova, T., Wang, G.* 2016 Anti-Staphylococcal biofilm effects of human cathelicidin peptides. ACS Medicinal Chemistry Letters, 7, 117-121.

Wang, G. 2015 Improved methods for classification, prediction, and design of antimicrobial peptides. Methods in Molecular Biology. 1268, 43-66.

Wang, G. 2014 Human Antimicrobial Peptides and Proteins. Pharmaceuticals 7, 545-594.

Wang, G. Hanke, M.L., Mishra, B., Lushnikova, T., Heim, C.E., Chittezham, Thomas V., Bayles, K.W., Kielian, T. 2014 Transformation of Human Cathelicidin LL-37 into Selective, Stable, and Potent Antimicrobial Compounds. ACS Chem. Biol. 9, 1997-2002.

Wang, G. 2013. Database-guided discovery of potent peptides to combat HIV-1 or Superbugs. Pharmaceuticals 6, 728-758. 

Mishra, B., Wang, G. 2012. Ab initio design of potent anti-MRSA peptides based on database filtering technology (DFT).J. Am. Chem. Soc. 134, 12426-12429.

Wang, G., Epand, R.F., Mishra, B., Lushnikova, T., Thomas, V.C., Bayles, K.W., Epand, R. 2012. Decoding the functional roles of cationic side chains of the major antimicrobial region of human cathelicidin LL-37. Antimicrob. Agents Chemother. 56, 845-856. 

Menousek, J., Mishra, B., Hanke, M.L., Heim, C.E., Kielian, T., Wang, G. 2012. Database screening and in vivo efficacy of antimicrobial peptides against methicillin-resistant Staphylococcus aureus USA300. Int. J. Antimicrob. Agents 39, 402-406.

Wu, W.K.K., Wang, G., Coffelt, S.B., Betancourt, A.M., Lee, C.W., Yu, J., Sung, J.J.Y., & Cho, C.H. 2010. Emerging roles of the host defense peptide LL-37 in human cancer and its potential therapeutic applications. Int. J. Cancer 127(8):1741-1747. Equal contributions.

Wang, G., Watson, K.M., Peterkofsky, A. & Buckheit, R.W. Jr. 2010. Identification of novel human immunodeficiency virus type 1 inhibitory peptides based on the antimicrobial peptide database. Antimicrob. Agents Chemotherapy. 54(3):1343-1346. PMCID: PMC2826022

Wang, G. 2008. Structures of human host defense cathelicidin LL-37 and its smallest antimicrobial peptide KR-12 in lipid micelles. J. Biol. Chem. 283:32637-32643. PDB entry: 2K6O; BMRB entry: 15876.

Li, Y., Li, X. & Wang, G. 2006. Cloning, expression, isotope labeling, and purification of human antimicrobial peptide LL-37 in Escherichia coli for NMR studies. Protein Exp. Purif. 47:498-505.

Li, X., Li, Y., Han, H-Y., Miller, D.W. & Wang, G. 2006. Solution structures of human LL-37 fragments and NMR-based identification of a minimal membrane-targeting antimicrobial and anticancer region. J. Am. Chem. Soc. 128:5776-5785. PDB entries: 2FBS; 2FBU; 2FCG.

Wang, Z. & Wang, G. 2004. APD: the antimicrobial peptide database. Nucleic Acids Res. 32:D590-D592. Web site http://aps.unmc.edu/AP/main.html; PMCID: PMC308759.

Books
Wang, G. (ed.) 2010. Antimicrobial Peptides: Discovery, Design and Novel Therapeutic Strategies. CABI, Oxfordshire, UK. ISBN 978-1845-9365-70.

For a detailed list of publications, click here.