Innate Immunity, Immuno-metabolism, Mitochondrial metabolism, Cell death, Sepsis, Colitis, Colitis-associated Cancer
Education and Training
B.S., Shandong University School of Medicine, Jinan, China (Clinical Medicine), 1998
M.S., Shandong University School of Medicine, Jinan, China (Pathophysiology), 2001
Ph.D., University of Michigan Medical School, Ann Arbor, MI (Molecular and Cellular Pathology), 2007
Post-doctoral training, UNC-Chapel Hill, Chapel Hill, NC (Immunology), 2008-2013
Zhao C, Gillette DD, Li X, Zhang Z, Wen H. Nuclear factor E2-related factor-2 (Nrf2) is required for NLRP3 and AIM2 inflammasome activation. J Biol Chem. 2014 Jun 13;289(24):17020-9
Wen H, Miao EA, Ting JP. New mechanisms of NLR-associated inflammasome activation. Immunity. 2013 Sep 19;39(3):432-41.
Lei Y*, Wen H*, Yu Y, Taxman DJ, Zhang L, Widman DG, Swanson KV, Wen KW, Damania BA, Moore CB, Giguère PM, Siderovski DP, Hiscott J, Razani B, Semenkovich CF, Chen X, Ting JP. NLRX1 and TUFM form a mitochondrial complex that regulates type 1 interferon and autophagy. Immunity. 2012 June 29;36(6):933-46. (Equal contribution)
Wen H*, Gris D*, Lei Y, Jha S, Zhang L, Huang MT, Brickey WJ, Ting JP. Fatty acid-induced NLRP3/ PYCARD inflammasome activation interferes with insulin signaling. Nat Immunol. 2011 May;12(5):408-15 (Equal contribution)
Beckley KD, Wen H, Ting JP. The inflammasome NLRs in immunity, inflammation and associated diseases. Annu Rev Immunol. 2011;29:707-35
Wen H, Lei Y, Eun So-Young, Ting JP. Plexin-A4-semaphorin 3A signaling is required for Toll like receptor- and sepsis-induced cytokine storm. J Exp Med. 2010 Dec 20;207(13):2943-57.
For a detailed list of publications, click here.