Category: Published Research
Features and risk factors of post-COVID-19 syndrome: Findings from a longitudinal study in Bangladesh
(The Lancet) A comprehensive study of the post-COVID syndrome (PCS) remains scarce in low-and middle-income countries. We assessed the prevalence, incidence rate, evolution over time, and risk factors of PCS among hospitalized (HS) and non-hospitalized (NHS) COVID-19 survivors. We undertook a prospective longitudinal study of COVID-19 survivors at months 1, 3, and 5 post-discharge or […]
Jan 3, 2023
‘Unique’ mix of COVID-19 variants in Australia a challenge for antiviral treatments, study finds
(Nature) Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) breakthrough infections in vaccinated individuals and reinfections in previously infected individuals have become increasingly common. Such infections highlight a broader need to understand the contribution of vaccination, including booster doses, and natural immunity to the infectiousness of individuals with SARS-CoV-2 infections, especially in high-risk populations with intense […]
Jan 3, 2023
Severe COVID-19 increases the risk of schizophrenia
(Psychiatry Research) The coronavirus SARS-CoV-2 invades the central nervous system, impacting the mental health of COVID-19 patients. We performed a two-sample Mendelian randomization analysis to assess the potential causal effects of COVID-19 on schizophrenia. Our analysis indicated that genetic liability to hospitalized COVID-19 was associated with an increased risk for schizophrenia (OR: 1.11, 95% CI: […]
Jan 3, 2023
The epidemiology of long COVID in US adults
(Clinical Infectious Diseases) We estimated the prevalence of long COVID and impact on daily living among a representative sample of adults in the United States (US). We conducted a population-representative survey, June 30-July 2, 2022, of a random sample of 3,042 United States adults aged 18 years or older and weighted to the 2020 US […]
Dec 27, 2022
The trajectory of COVID-19 cardiopulmonary disease: insights from an autopsy study of community-based, pre-hospital deaths
(ERS Publications) Post mortem examination of lung and heart tissue has been vital to developing an understanding of COVID-19 pathophysiology; however studies to date have almost uniformly used tissue obtained from hospital-based deaths where individuals have been exposed to major medical and pharmacological interventions.
Dec 27, 2022
Persistent post–COVID-19 smell loss is associated with immune cell infiltration and altered gene expression in olfactory epithelium
(Science) SARS-CoV-2 causes profound changes in the sense of smell, including total smell loss. Although these alterations are often transient, many patients with COVID-19 exhibit olfactory dysfunction that lasts months to years. Although animal and human autopsy studies have suggested mechanisms driving acute anosmia, it remains unclear how SARS-CoV-2 causes persistent smell loss in a […]
Dec 27, 2022
Saliva antibody-fingerprint of reactivated latent viruses after mild/asymptomatic COVID-19 is unique in patients with myalgic-encephalomyelitis/chronic fatigue syndrome
(Frontiers in Immunology) Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a chronic disease considered to be triggered by viral infections in a majority of cases. Symptoms overlap largely with those of post-acute sequelae of COVID-19/long-COVID implying common pathogenetic mechanisms. SARS-CoV-2 infection is risk factor for sustained latent virus reactivation that may account for the symptoms of […]
Dec 27, 2022
SARS-CoV-2 infects adipose tissue in a fat depot- and viral lineage-dependent manner
(Nature) Visceral adiposity is a risk factor for severe COVID-19, and a link between adipose tissue infection and disease progression has been proposed. Here we demonstrate that SARS-CoV-2 infects human adipose tissue and undergoes productive infection in fat cells. However, susceptibility to infection and the cellular response depends on the anatomical origin of the cells […]
Dec 20, 2022
Data-driven identification of post-acute SARS-CoV-2 infection subphenotypes
(Nature) The post-acute sequelae of SARS-CoV-2 infection (PASC) refers to a broad spectrum of symptoms and signs that are persistent, exacerbated or newly incident in the period after acute SARS-CoV-2 infection. Most studies have examined these conditions individually without providing evidence on co-occurring conditions. In this study, we leveraged the electronic health record data of […]
Dec 20, 2022
Chemosensory deficits are best predictor of serologic response among individuals infected with SARS-CoV-2
(PLoS) Smell and taste alteration are closely linked to infection with SARS-CoV-2 and may be associated with a more indolent disease course. Serologic response rates among individuals with mild disease remains limited. We sought to identify whether chemosensory changes associated with COVID-19 were predictive of a serologic response.
Dec 16, 2022