University of Nebraska Medical Center

Antimicrobial Desensitization

Protocols for antibiotic desensitization have been developed by the Antimicrobial Stewardship Program in collaboration with the UNMC Division of Allergy and Immunology. They are approved for use at Nebraska Medicine by the Antimicrobial Subcommittee, Pharmacy & Therapeutics Committee, and Medical Executive Committee. They can be utilized in patient populations with a history of severe drug allergy who need a specific medication. It should be noted that antibiotic desensitization protocols do not eliminate the risk of anaphylaxis. Thus, antibiotic desensitization should only be considered when other alternatives have been exhausted. Antibiotic desensitization protocols should only be performed in a monitored setting in which resuscitative efforts could be immediately employed as needed. Inpatient antibiotic desensitization can be ordered in One Chart using the order set entitled "General IV Desensitization."