College of Medicine

- Admissions Overview
- - MD Program
    UNMC's rigorous academics, diverse clinical experiences and supportive environment put you on the path to becoming a skilled, compassionate physician.
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    UNMC prepares medical degree students to meet the needs of patients through clinical practice, biomedical science and research, problem-solving and compassion.
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    Review opportunities for state licensure following completion of the MD program in the College of Medicine at UNMC.
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    A combined MD-MBA degree equips you with the tools you need to become highly skilled in both management and medicine.
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    Pursue your passion for public health and medicine with a combined MD-MPH and help solve complex health problems.
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- Education Overview
- - Curriculum
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    Review requirements for students pursuing an MD at the UNMC College of Medicine to graduate and receive their degree.
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    Active participation in community service provides critical opportunities to apply skills and knowledge gained in medical school and develop a sense of empathy.
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    The MD honors thesis encourages students to engage in scientific research during medical education and become eligible to graduate with honors.
- Research Overview
- Internal Grants
  The College of Medicine has a variety of research-related grant and award opportunities available to UNMC faculty.
- Comparative Effectiveness Research
  The Comparative Effectiveness Research (CER) program identifies knowledge gaps in the effectiveness of clinical care and improves CER in these areas.
- Great Plains IDeA-CTR
  The Great Plains IDeA-CTR is a collaborative effort between nine regional institutions that provides training, resources. and funding to regional researchers.
- Research and Development Committee
  The Research and Development Committee handles funding opportunities for faculty, including the Bridge Funding program, and student research opportunities.
- Student Opportunities
  The College of Medicine provides a variety of research opportunities for both current and prospective UNMC students.
- Residencies & Fellowships Overview
- Graduate Medical Education Programs
  UNMC's dozens of programs--including nearly 20 in internal medicine--allow residents and fellows a variety of specialties.
- House Officer Resources
  Resources for residents and fellows include an assistance program, a private wellness lounge and housing assistance.
- Research
  We aim to facilitate house officers’ involvement in research in the areas of patient safety, quality improvement, healthcare disparities and education research.
- Salary and Benefits
  Paid vacation and professional leave, health insurance and meal allowances are just a few of the benefits residents receive in addition to their yearly salary.
- Contact Us
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- About DEI
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- Pathway Programs
  We are developing a diverse workforce through innovative programming that inspires K-12 and college students to choose careers in medicine and research.
- DEI in the Curriculum
  Diversity, equity and inclusion concepts are included in all three phrases of the College of Medicine's curriculum.
- Community Engagement
  We center our community partner needs particularly in marginalized and underserved populations.
- Our Team
  Contact our office for questions, consults on diversity, equity, and inclusion.
Departments

— College of Medicine — Department of Internal Medicine — Divisions — Infectious Diseases — Antimicrobial Stewardship Program — Protected Antimicrobials — Dalbavancin

Dalbavancin

In Spring 2019, the Pharmacy and Therapeutics Committee voted to add Dalbavancin to the formulary of the outpatient infusion center. Its use is currently restricted to prescribers from Infectious Diseases services only.

Efficacy

Dalbavancin is a lipoglycopeptide antibiotic derived from teicoplanin, an analog of vancomycin. It possesses a similar spectrum of activity to vancomycin with potent activity against Gram-positive microorganisms, including Streptococcus spp., Enterococcus spp., and both methicillin-susceptible and -resistant Staphylococcus aureus (MSSA and MRSA). It also has activity against some vancomycin-intermediate S. aureus (VISA). However, it is not active against most vancomycin-resistant Enterococcus spp. and all Gram-negative pathogens. It is currently indicated for the treatment of acute bacterial skin and skin structure infections (ABSSSIs). In two phase III trials that informed its approval, dalbavancin was shown to be non-inferior to intravenous (IV) vancomycin with optional switch to oral linezolid. Additionally, data has become available suggesting that it may also have a role in the treatment of other sources of infection, most notably osteomyelitis and endocarditis.

Safety

The pivotal clinical trials for the use of dalbavancin in ABSSSI showed that it was generally well tolerated, demonstrating that the majority of adverse effects were designated as mild or moderate. The most common reported were rash, headache, nausea, vomiting, and diarrhea.

Uniqueness

In comparison to the other antibacterial agents that also have activity against resistant Gram-positive pathogens such as vancomycin, daptomycin, linezolid, tedizolid, telavancin, and oritavancin, positive characteristics of dalbavancin include:

Extended half-life
- Once weekly dosing
Short infusion time (30 minutes)
Favorable adverse effect profile
- Does not prolong prothrombin time (PT) or activated partial thromboplastin time (aPTT)
No dosage-adjustment recommended for hemodialysis
Therapeutic drug monitoring is not routinely indicated

Additional information