Research
Our faculty members are dedicated to conducting research studies and clinical trials to find better ways to treat patients with kidney disease.
Research interests are listed on faculty pages.
Our fellows have had a track record of success in the initiation and completion of research projects which have led to presentations at national and international meetings as well as publications in renowned journals.Our fellows are also offered the opportunity to obtain research experience in the division. We offer extensive research training in renal physiology, renal pathology, transplantation immunology, molecular biology and biochemistry, hypertension, and related disciplines.
The lab of Dr. Roslyn Mannon is focused on translational studies of late kidney allograft outcomes. There are two main projects in the laboratory: understanding mechanisms of calcineurin inhibitor kidney injury (CNI nephrotoxicity) and studying the mechanisms of late kidney transplant rejection.
The research team uses mouse models to study these processes and is actively collaborating with other research groups on campus to discover new therapies. The lab recently identified a novel pathway of injury mediated by the CNIs cyclosporine and tacrolimus. In this work, these agents cause metabolic dysfunction in the proximal tubular epithelium of the kidney leading to a pro-fibrogenic mileu.
The Mannon Lab also serves as a sample biorepository for NIAID funded clinical trials in novel immunosuppressive agents in kidney transplants. These studies include cell based and novel biologic regimens. Members of the Nephrology Clinical Research team also include Kathleen Tinley, Thad Buster and Carol Carney.
A prominent collaboration with Dr. Peter Mannon’s lab is ongoing and studies the changes in gut microbiome following transplantation. The microbiome alteration can lead to metabolic syndrome, which is an important contributor to the very common post-transplantation cardiovascular dysfunction.
The team has been working closely with multiple core facilities, such as the UNMC Advance Microscopy Core Facility and the Preclinical Imaging Center and Multiphoton Intravital and Tissue Imaging directed by Dr. Heather Jensen-Smith, the UNMC Genomics Core Facility directed by Dr. Jim Eudy, and the Seahorse Core and Flow Cytometry Facility.
Lab Team Members
Divya Gnanadhas, PhD
Instructor
Hongjun Wei, BS
Researcher
Hongjun's research interest is the differentiation of monocytes to macrophage-like cells polarized into M1 or M2 phenotypes and the impact of kidney clinical drugs affecting this pathway.
