Luke D. Handke, PhD

Department Affiliations
Senior Scientist, Fey Lab

Education and Training
BS (summa cum laude), Biology, Kansas State University, 1999
PhD, Pathology & Microbiology, University of Nebraska Medical Center, Omaha, NE, 2005

Notable Publications
Rupp, M. E., S. J. Medcalf, P. D. Fey, L. D. Handke, and N. D. Marion.  2003. Monsel's solution: a potential vector for nosocomial infection? Infect Control Hosp Epidemiol 24:142-4.

Handke, L. D., K. M. Conlon, S. R. Slater, S. Elbaruni, F. Fitzpatrick, H. Humphreys, W. P. Giles, M. E. Rupp, P. D. Fey, and J. P. O'Gara.  2004. Genetic and phenotypic analysis of biofilm phenotypic variation in multiple Staphylococcus epidermidis isolates. J Med Microbiol 53:367-374. 

Handke, L. D., S.R. Slater, K.M. Conlon, S. T. O’Donnell, M.E. Olson, K.A. Bryant, M.E. Rupp, J.P. O’Gara, and P.D. Fey.  2007.  σB and SarA independently regulate polysaccharide intercellular adhesin production in Staphylococcus epidermidis.  Can J Microbiol 53:82-91.

Handke, L. D., K. L. Rogers, M. E. Olson, G. A. Somerville, T. J. Jerrells, M. E. Rupp, P. M. Dunman, and P. D. Fey.  2008.  Staphylococcus epidermidis saeR is an effector of anaerobic growth and a mediator of acute inflammation.  Infect Immun 76:141-52.

Handke, L. D., R. P. Shivers, and A. L. Sonenshein.  2008.  Interaction of Bacillus subtilis CodY with GTP.  J Bacteriol 190:798-806.

Villapakkam A. C.*, L. D. Handke*, B. R. Belitsky, V. M. Levdikov, A. J. Wilkinson, and A. L. Sonenshein.  2009.  Genetic and biochemical analysis of the interaction of Bacillus subtilis CodY with branched-chain amino acids.  J Bacteriol 191:6865-76.

(* These authors contributed equally to the work.)  

Château A., W. van Schaik, P. Joseph, L. D. Handke, S. M. McBride, F. M. Smeets, A. L. Sonenshein, and A. Fouet.  2013.  Identification of CodY Targets in Bacillus anthracis by Genome-Wide In Vitro Binding Analysis.  J Bacteriol 195:1204-13.

Handke, L. D., J. C. Hawkins, A. A. Miller, K. U. Jansen, A. S. Anderson. 2013. Regulation of Staphylococcus aureus MntC Expression and Its Role in Response to Oxidative Stress.  PLoS One 8:e77874.

Gribenko A.V., K. Parris, L. Mosyak, S. Li, L. Handke, J. C. Hawkins, E. Severina, Y. V. Matsuka, and A. S. Anderson.  2016. High Resolution Mapping of Bactericidal Monoclonal Antibody Binding Epitopes on Staphylococcus aureus Antigen MntC. PLoS Pathog 12:e1005908.

Handke, L. D., A. V. Gribenko, Y. Timofeyeva, I. L. Scully, and A. S. Anderson.  2018.  MntC-dependent manganese transport is essential for Staphylococcus aureus oxidative stress resistance and virulence.  mSphere 18; 3(4).

Buurman E.T., Y. Timofeyeva, J. Gu, J. H. Kim, S. Kodali, Y. Liu, T. Mininni, S. Moghazeh, D. Pavliakova, C. Singer, S. Singh, L. D. Handke, J. Lotvin, A. K.Prasad, I. L. Scully, R. G. K. Donald, K. U. Jansen, and A. S. Anderson.  2019.  A novel hexavalent capsular polysaccharide conjugate vaccine (GBS6) for the prevention of neonatal group B streptococcal infections by maternal immunization.  J Infect Dis pii: jiz062.

Book chapters
Fey, P. D., and L. D. Handke.  “Current perspectives on the regulation of the ica operon and biofilm formation in Staphylococcus epidermidis.”  Biofilms, Infection, and Antimicrobial Therapy.  Eds. J. L. Pace, M. E. Rupp, and R. G. Finch.  Boca Raton, FL:  CRC Press, 2006.  187-203.

Handke, L. D., and M. E. Rupp.  In vivo models for the study of biomaterial-associated infection by biofilm-forming staphylococci.”  Biofilms, Infection, and Antimicrobial Therapy.  Eds. John L. Pace, Mark E. Rupp, and Roger G. Finch.  Boca Raton, FL:  CRC Press, 2006.  289-303.

RSV F protein mutants.  Inventors:  Cai, P., Y. Che, K. S. Efferen, L. D. Handke, A. V. Gribenko, P. R. Dormitzer, X. Song, X. Qiu, K. A. Swanson, L. Nunez, K. R. Tompkins, S. Kodali, A. K. Prasad, M. E. Ruppen, X. Xu.  Granted in United States:  2018.