The Histocompatibility Laboratory, under the direction of Dr. Jesse Cox provides testing services to support solid organ and bone marrow transplant programs at Nebraska Medicine, as well as other programs throughout the region. The laboratory also provides state-of-art human leukocyte antigen (HLA) typing to assist in assessment of disease associations and in a variety of medical situations, including platelet transfusion support and drug sensitivity profiling.
A broad menu of histocompatibility testing services are offered including:
- HLA-A, B, C, DR, DQ and DP loci typing, using molecular methods, ranging in resolution from low (antigen-level) to high (allele-level) by next generation sequence analysis.
- HLA antibody identification and monitoring by solid phase bead methodology for antibodies to HLA-A, B, C, DR, DQ, and DP.
- Lymphocyte crossmatch by both complement-dependent cytotoxicity (CDC) and flow cytometric methods.
The laboratory is accredited by both the College of American Pathologists (CAP) and American Society for Histocompatibility and Immunogenetics (ASHI). Laboratory technologists are certified by the American Society of Clinical Pathology (ASCP), including five who have earned the “Histocompatibility Specialist” designation (CHS) from American Board of Histocompatibility and Immunogenetics (ABHI).
The laboratory directors and staff are available for consultation. General questions regarding testing availability can be directed to Sophie Hauxwell (402) 559-5104 or to the laboratory (402) 559-7625. Medical or technical questions can be directed to either Dr. Cox at (402) 559-4186.