COM research highlights, July 2023

Kelsey Klute, MD

Kelsey Klute, MD

The UNMC College of Medicine received grant and funding awards representing more than $3 million in new funding in May.

Kelsey Klute, MD, internal medicine-oncology/hematology, received a grant of $367,440 from the Pancreatic Cancer Action Network for Precision Promise.

Karen Gould, PhD, genetics, cell biology and anatomy, received a grant of $300,000 from U.S. Army/USAMRAA/CDMRP for a study of somatic mutations in non-Ig loci in autoreactive B cells as drivers of lupus pathogenesis and disease heterogeneity.

Gurudutt Pendyala, PhD, anesthesiology, received a grant of $259,304 from DHHS/NIH/NIDA for a study of mechanisms underlying prescription opioid use post social defeat in HIV+ adolescents.

Jeffrey Salomon, MD, pediatrics-critical care, received a grant of $231,000 from the national American Heart Association for a study of the impact of intestinal dysbiosis and inflammatory metabolites after pediatric surgery with cardiopulmonary bypass.

Jill Beck, MD, pediatrics-hematology/oncology, received seven subawards totaling $146,400 from Children’s Hospital & Medical Center-Omaha.

Maegen Wallace, MD, orthopaedic surgery, received a grant of $90,295 from the Baylor College of Medicine for the Brittle Bone Disorders Consortium of the Rare Disease Clinical Research Network.

Christopher Conrady, MD, PhD, ophthalmology and visual sciences, received a grant of $90,000 from the Knights Templar Eye Foundation Inc for a study on acute retinal necrosis in children.

Joshua Mammen, MD, PhD, surgery-surgical oncology, received a grant of $60,000 from DHHS/NIH/NCI as COG CHMC subaward – per case reimbursement.

Eleanor Gradidge, MD, pediatrics-critical care, received a grant of $58,714 from the University of Alabama-Birmingham for a trial of azithromycin for RSV-induced respiratory failure in children.

Jairam Krishnamurthy, MD, internal medicine-oncology/hematology, received a grant of $42,868 from the Big Ten Cancer Consortium for a study of Alpelisib (BYL719) in combination with continued endocrine therapy following progression on endocrine therapy in hormone receptor positive, HER2 negative, PIK3CA mutant metastatic breast cancer.

Andrew Vasey, MD, internal medicine-general medicine, received a grant of $28,596  from the University of Mississippi Medical Center for a study of Immulina as an antiviral immune modulator for patients with PASC and persistent inflammation.

Sara Bares, MD, internal medicine-infectious diseases, received a grant of $17,005 from Massachusetts General Hospital for 1/2 REPRIEVE extension for trial completion.

Kuan-Hua Chen, PhD, neurological sciences, received a grant of $13,999 from the Nebraska Bankers Association Equipment Grants/U.N. Foundation for enhancing UNMC’s Neuroimaging Core for Magnetoencephalography (MEG) and autonomic nervous system monitoring.

Shilpa Buch, PhD, pharmacology and experimental neurosciences, received a grant of $7,703 from Florida International University for studying pharmacokinetic, pharmacodynamic, and toxicological interactions among opioids and Cabotegravir.

Vikas Kumar, PhD, genetics, cell biology and anatomy, received a grant of $5,486 from the Nebraska Bankers Association Equipment Grants/U.N. Foundation for NBA – Probe Sonicator.

Industry-sponsored grants and contracts:

The following industry-sponsored grants and contracts were received.

Douglas Stoller, MD, PhD, internal medicine-cardiovascular, received funding for a study to evaluate Mavacamten in adults with symptomatic non-obstructive hypertrophic cardiomyopathy.

Natalia Castillo Almeida, MD, internal medicine-infectious diseases, received funding for a phase 3 master protocol to evaluate the safety, tolerability and immunogenicity of respiratory syncytial virus (RSV) prefusion F subunit vaccine in adults at high risk of severe RSV disease.

Kerry Rodabaugh, MD, obstetrics-gynecology, received funding for a study of SQZ-eAPC-HPV as monotherapy and in combination with immune checkpoint inhibitors in patients with HPV16+ recurrent, locally advanced or metastatic solid tumors.

Jason Payne, MD, internal medicine-cardiovascular, received funding for the Abbott atrial fibrillation post-approval study; also for an assessment of implantable CCM in the heart failure group with higher ejection fraction.

Paul Fey, PhD, pathology and microbiology, received funding for evaluation of VITEK REVEAL Rapid AST System vs. MicroScan for antimicrobial susceptibility testing of gram-negative bacteria from positive blood cultures.

Joseph Americo Fernandes, MD, neurological sciences, received funding for an intermediate expanded access protocol (EAP).