The UNMC College of Medicine recently received grants and awards representing $4.4 million in new funding. Awards included:
- Siddappa Byrareddy, PhD, pharmacology and experimental neuroscience, received a grant of $844,946 from the DHHS/NIH/NIDA to study cannabinoid inhibition of CNS inflammasome activation via modulation of the gut-brain axis.
- Howard Gendelman, MD, pharmacology and experimental neuroscience, received a grant of $736,036 from the DHHS/NIH/NIMH to study targeted lipid nanoparticles for gene therapeutics delivery approach to eradicating HIV reservoirs.
- Shilpa Buch, PhD, pharmacology and experimental neuroscience, received a grant of $441,154 from the DHHS/NIH/NIDA for the study “Molecular interplay of HIV Tat, cocaine, and cART in microglial pyroptosis: Role of NLRP3 inflammasome.”
- Russell McCulloh, MD, pediatrics-hospitalists, received a grant of $89,194 from the University of Kansas Medical Center for implementation of the new pediatric obesity clinical practice guidelines in rural families and clinics: a randomized clinical trial.
- Joshua Bies, MD, pediatrics-hematology/oncology, received a grant of $27,026 from the Pediatric Blood and Marrow Transplant Consortium for a trial of low vs. moderate exposure Busulfan for infants with severe combined immunodeficiency (SCID) receiving TCRaß+/CD19+ depleted transplantatiol.
- Roslyn Mannon, MD, internal medicine-nephrology, received a grant of $2,766 from the Hennepin Healthcare Research Institute for staffing.
- Angela Yetman, MD, pediatrics-cardiology, received a grant of $700 from Baylor College of Medicine for “Outcome Modeling and Decision Making for Hereditary Thoracic Aortic Disease Using the Collaborative for Longitudinal Aortic Imaging in the Young.”
Industry-sponsored grants and contracts:
The following industry-sponsored grants and contracts were received.
- Mara Seier, MD, neurological sciences, received funding for a trial of Lu AF82422 in participants with Multiple System Atrophy.
- Ronald Zolty, MD, PhD, internal medicine-cardiovascular, received funding to assess the efficacy and safety of TX000045 After 24 weeks of treatment in patients with pulmonary hypertension secondary to heart failure with preserved ejection fraction; and funding to assess the safety and efficacy of Vutrisiran in patients with transthyretin amyloidosis with cardiomyopathy.
- Kelsey Klute, MD, internal medicine-oncology/hematology, received funding for a trial of Quemliclustat and chemotherapy vs. placebo and chemotherapy in patients with treatment-naive metastatic pancreatic ductal adenocarcinoma.
- Rana Zabad, MD, neurological sciences, received funding to evaluate the safety and clinical activity of Azercabtagene Zapreleucel in participants with B-cell mediated autoimmune disorder.
- Jason Payne, MD, internal medicine-cardiovascular, received funding for “PULSED AF Post-Approval Study, an Addendum to the PulseSelect PFA Global Registry.”
- Bhavina Sharma, MD, internal medicine-oncology/hematology, received funding for a study of inhaled KB707 in patients with advanced solid tumor malignancies affecting the lungs.
- Hani Haider, PhD, orthopaedic surgery, received funding for an in vitro wear durability study of the Maxx Orthopedics unicondylar knee replacement system.