Medical research highlights, November, 2023

Don Coulter, MD

Don Coulter, MD

The UNMC College of Medicine received grant and funding awards representing more than $13.6 million in new funding in September.

Don Coulter, MD, pediatrics-hematology/oncology, received a $2.7 million grant from NE DHHS for the CHRI Pediatric Cancer Research Group (State Funds).

Lynda Harris, PhD, obstetrics and gynecology, received a $2.65 million grant from DHHS/NIH/NIDA for a study on strategies to define and mitigate the placental and fetal alterations caused by maternal oxycodone exposure.

John Davis, PhD, obstetrics and gynecology, received a $1.75 million grant for a study on Metabolic and Mitochondrial Signals During Ovulation from the U.S. Department of Agriculture; a $424,584 grant renewal from Wichita State University for a study on The Aging Pituitary/Gonadal Axis, Project 2: Role of Glycosylation in FSH Signaling in FSH Target Cells; and a $422,125 grant from DHHS/NIH/NICHD for a study on elucidating the role of YAP and TAZ in the aging human ovary.

Shilpa Buch, PhD, pharmacology and experimental neuroscience, received a $1.15 million grant from the University of California – San Diego for a study on single cell determinants of brain in the context of viral persistence in SIV/cART/cocaine non-human primates.

Yulong Li, MD, PhD, emergency medicine, received a $594,440 grant from the DHHS/NIH/NHLBI for a study on optogenetic silencing to achieve antiarrhythmic effect of renal denervation in chronic heart failure.

Bin Duan, PhD, internal medicine-cardiovascular, received a grant of $ 437,331 from DHHS/NIH/NINDS for a study on the development of optoelectronically active nerve adhesive for accelerating peripheral nerve repair.

Paul Thomes, PhD, internal medicine-GI, received a grant of $402,938 from DHHS/NIH/NIAAA for a study on the Role of Lysosome Damage in ALD Pathogenesis.

Gus Wang, PhD, pathology/microbiology, received a $383,750 grant from DHHS/NIH/NIAID for a study on novel antimicrobials to combat Gram-negative bacteria.

Scot Ouellette, PhD, pathology/microbiology, received a $241,875 grant from DHHS/NIH/NIAID for a study on Characterizing the Redoxome of Chlamydia and Its Host Cell.

Hanjun Wang, MD, anesthesiology, received a $230,250 grant from DHHS/NIH/NHLBI for a study on Novel Stellate Ganglia Chemo-ablation Approach to Treat Cardiac Arrhythmia and Cardiac Remodeling in Heart Failure.

Ann Anderson Berry, MD, PhD, pediatrics-newborn medicine, received a $200,000 grant from DHHS/HRSA for the Nebraska Perinatal Quality Improvement Collaborative, Striving for Excellence in Perinatal Care.

P. James Murphy, MD, internal medicine-pulmonary, received $179,030 grant from the Cystic Fibrosis Foundation for the CFF Center Adult Program.

Jingwei Xie, PhD, surgery-transplant, received a $109,125 grant from NE DHHS – LB606 for a study on Ritonavir-eluting Nanofiber Scaffolds for Inhibition of Heterotopic Ossification.

Ricia Hyde, PhD, biochemistry and molecular biology, received a $109,125 grant from NE DHHS – LB606 for a study on Hematopoietic Stem Cells and Bone Marrow Failure.

Bryant England, MD, PhD, internal medicine-rheumatology, received a $100,000 grant from the Rheumatology Research Foundation for a study on Quantitative Imaging Analysis of Chest Computerized Tomography in Rheumatoid Arthritis-Associated Interstitial Lung Disease — CDA Supplement.

Siddappa Byrareddy, PhD, pharmacology and experimental neuroscience, received a $93,942 grant from the University of Minnesota for a study on Targeting HIV-specific CAR T cells to the gut for the durable remission of HIV.

Santhi Gorantla, PhD, pharmacology and experimental neuroscience, received a $76,750 grant from George Washington University for a study on novel pathogenic mechanism of HIV-associated neurocognitive disorders.

Laura Anne Graeff-Armas, MD, PhD, internal medicine-DEM, received a grant of $50,109 from the Nebraska Educational Biomedical Research Association for as Nebraka ICA for ZEUS Project for Jenna Eggert.

Julia Bridge, MD, pathology/microbiology, received a $36,289 grant from the Research Institute at Nationwide Children’s Hospital for a study on the molecular annotation of rhabdomyosarcoma tissue microarrays (TMAs).

Scott Campbell, PhD, pathology/microbiology, received a $35,000 grant from the College of American Pathologists for a study on In Vitro Diagnostic Encoded Test Result Data Exchange, Validation, and Quality Improvement.

Amanda Macke, PhD, biochemistry and molecular biology, received a grant of $33,227 from DHHS/NIH/NIA for a study on the impact of alcohol-induced ATF6-mediated ER stress and Golgi disorganization on pro-metastatic glycosylation of integrins in prostate cancer.

Cyrus Desouza, MBBS, internal medicine/DEM, received a $27,281 grant from the Nebraska Educational Biomedical Research Association for a study on NEBRA ICA for Ramesh Ramalingam.

Ashley Deschamp, MD, pediatrics-pulmonology, received a $19,129 grant from Creighton University for a study on Genetic Markers for Susceptibility or Resistance to Ototoxicity.

Melissa Cullimore, MD, PhD, pediatrics-critical care, received a $19,092 grant from the Research Institute at Nationwide Children’s Hospital for a study on the PediAtric ReseArch of Drugs, Immunoparalysis and Genetics during MODS (PARADIGM).

Industry-sponsored grants and contracts:

Brett Duncan, MD, surgery-cardiothoracic surgery, received funding from AtriCure, Inc. for the Left Atrial Appendage Exclusion for Prophylactic Stroke Reduction Trial (LeAAPS).

Shaheed Merani, MD, PhD, surgery/surgery-transplant, received funding from TransMedics for the OCS Liver Perfusion (OLP-II) Registry.

Christopher R D’Angelo, MD, internal medicine-oncology/hematology, received funding from Ono Pharma USA, Inc. for an open-label phase II study to investigate the efficacy, safety, and pharmacokinetics of tirabrutinib in patients with Primary Central Nervous System Lymphoma (PCNS).

Scott Campbell, PhD, pathology/microbiology, received funding from Synensys, LLC for FDA Synensys BAA PMWP 214; BAA No. FDABAA-22-00123.

Ronald Zolty, MD, PhD, internal medicine-cardiovascular, received funding from Analog Devices, Inc. for a study on the Feasibility and Efficacy Study of the CardioPulmonary Monitoring (CPM) System in Patients with Chronic Heart Failure (CPM Beta Study).

Hani Haider, PhD, orthopaedic surgery, received funding from Globus Medical, Inc. for Work Order: Constraint, Range of Motion and wear Testing of Two Globus Total Knee Replacement systems, and Wear Testing of one system.

Sarah Holstein, MD, PhD, internal medicine-oncology/hematology, received funding from Prothena Biosciences Limited for a Phase 3, Randomized, Multicenter, Double-Blind, Placebo-Controlled, Efficacy and Safety Study of Birtamimab Plus Standard of Care vs. Placebo Plus Standard of Care in Mayo Stage IV Subjects with Light Chain (AL) Amyloidosis (AFFIRM-AL).

Trevor Vanschooneveld, MD, internal medicine-infectious diseases, received funding from Ferring Pharmaceuticals A/S for a study of REBYOTA for the Prevention of Recurrence of Clostridioides Difficile Infection (CDI) in Adult Patients: An Observational Study (ROAR).

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