The UNMC College of Medicine received grant and funding awards representing $5,357,140 in new funding in March.
- Irving R. Zucker, PhD, cellular and integrative physiology, received a grant of $575,866 from DHHS/NIH/NHLBI for a study on Nrf2 regulation of oxidative stress in heart failure and extra vesicular communication.
- Punita Dhawan, PhD, biochemistry and molecular biology, received a grant of $571,142 from DHHS/NIH/NCI for a study on the impact of CLDN1 inhibition on chemoresistance and metastasis of colon cancer.
- Sarah Holstein, MD, PhD, internal medicine-oncology/hematology, received a grant of $515,150 from the DHHS/NIH/NCI to study geranylgeranyl diphosphate synthase inhibitor therapy for multiple myeloma.
- Ann Anderson Berry, MD, PhD, pediatrics, received a grant of $268,740 from Creighton University to study Clinical factors in aminoglycoside-induced ototoxicity. Dr. Anderson Berry also received a grant of $96,172 from Harvard College for the Health’s Early Roots & Origins (HERO) program.
- Stephen Gliske, PhD, neurosurgery, received a grant of $234,584 from the University of Michigan for the creation of state of wakefulness/sleep monitor for infants in the neonatal intensive care unit.
- James McClay, MD, emergency medicine, received a grant of $183,128 from the University of Missouri-Columbia for the advancement of PCORnet infrastructure: Clinical research network. Dr. McClay also received funding for a COVID-19 Electronic Health Data Initiative.
- Wallace Thoreson, PhD, ophthalmology and visual sciences, received a grant of $165,144 from Yale University for a study on synaptic transmission at retinal ribbon synapse.
- Siddappa Byrareddy, PhD, pharmacology and experimental neuroscience, received a grant of $163,831 from the NIH to study epigenetic mechanisms underlying cannabinoid modulation of neuroinflammation in HIV/SIV infection.
- Rebekah Dawson, PhD, cellular and integrative physiology, received a grant of $86,642 from Medical College of Wisconsin for a study on surfaceome of human beta and non-beta islet cells.
- Russell McCulloh, MD, pediatrics, received a grant of $76,468 from the Fred Hutchinson Cancer Research Center for CoVID-19 Prevention Network (CoVPN) site preparedness funding.
- Michael Daseke, cellular and integrative physiology, received a grant of $55,049 from the DHHS/NIH/NHLBI for a study of infarct macrophage secretome components coordinate neutrophil degranulation and attenuate wall thinning.
- Cyrus Desouza, MBBS, internal medicine-DEM, received a grant of $23,324 from the Nebraska Educational Biomedical Research Association as an ICA for Katelyn Kelley.
Industry-sponsored grants and contracts:
The following industry-sponsored contracts and foundation grants were received. Information on clinical trials enrolling patients at UNMC can be found here.
- Sara Bares, MD, internal medicine-infectious diseases, funding for a Phase IIb, randomized, partially blind, active controlled, dose-range finding study of GSK3640254 compared to a reference arm of dolutegravir, each in combination with nucleoside reverse transcriptase inhibitors, in HIV-1 infected antiretroviral.
- Andrew Goldswieg, MD, internal medicine-cardiovascular, received funding to study embolic protection in the management of patients with non-valvular atrial fibrillation.
- Apar Ganti, MD, internal medicine-oncology/hematology, received funding for a study to evaluate the safety, tolerability and pharmacokinetics of TAB004 in subjects with advanced solid malignancies including lymphoma.
- Ronald Zolty, MD, PhD, internal medicine-cardiovascular, received funding for a prospective, randomized, double-blind, multicenter, placebo-controlled parallel group, adaptive Phase 3 study with open-label extension to evaluate efficacy and safety of macitentan 75 mg in inoperable or persistent/recurrent chronic thom.
- John Um, MD, surgery, received funding for a portable organ care system heart for resuscitation, preservations and assessment of hearts from donors after circulatory death continue access protocol.
- Julie Vose, MD, internal medicine-oncology/hematology, received funding to study oral LOXO-305 in patients with previously treated chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) or non-Hodgkin lymphoma.
- Robert Bociek, MD, internal medicine-hematology/oncology, received funding for a study of brentuximab vedotin or placebo in combination with lenalidomide and rituximab in subjects with relapsed or refractory diffuse barge B-cell lymphoma.
- Andjela Drincic, MD, internal medicine-DEM, received funding for a study of the safety of relacorilant in the treatment of the signs and symptoms of endogenous cushing syndrome.
- Daniel Murman, MD, neurological sciences, received funding for a clinical trial to evaluate the efficacy and safety of sodium oligomannate in treatment of mild to moderate Alzheimer’s disease.
- Avyakta Kallam, MD, internal medicine-oncology/hematology, received funding for a study of the safety, pharmacokinetics and pharmacodynamics of JNJ-67856633, an inhibitor of MALT1, in participants with NHL and CLL.
- Melissa Muff-Luett, MD, pediatrics, received funding for a study investigating the efficacy, safety and pharmacokinetics of Roxadustat for treatment of anemia in pediatric patients with chronic kidney disease.
- Hani Haider, PhD, orthopaedic surgery, received funding for an in-vitro wear durability study of the Optimotion total knee replacement system with left femoral components paired with right tibial components.
- Jill Poole, MD, internal medicine-allergy and immunology, received funding for an observational, non-interventional, study of patients with hereditary angioedema in the United States and Canada.
- Scott Westphal, MD, internal medicine-nephrology, received funding for a Trugraf long-term clinical outcomes study.
- Carol Toris, PhD, ophthalmology and visual sciences, received funding for a work order: aqueous humor dynamics.