Due to the nature of making gene knockout mice or transgenic mice, MGE does NOT guarantee that you will get the desired genetically manipulated mouse strain. We have no control over toxicity issues: the transgene may be deleterious for embryonic development. The targeting construct may be ineffective, and your gene knockout allele may have a negative effect on development despite the fact that we are using ES cells that have proven germline capacity. MGE does guarantee ‘best effort’: we will try every means at our disposal to generate the mouse strain necessary for your research project.