New investigator: Karuna Rasineni, PhD

January 24, 2022

Image with caption: Karuna Rasineni, PhD

Karuna Rasineni, PhD

This profile is part of a series to highlight the researchers who will be honored at a ceremony on Feb. 24 for UNMC's 2021 Scientist Laureate, Distinguished Scientist, New Investigator and Community Service to Research Award recipients.

The New Investigator Award

The New Investigator Award is given to outstanding UNMC scientists who, in the past two years, have secured their first funding from the National Institutes of Health, the Department of Defense or other national sources. New Investigator Award recipients also need to demonstrate scholarly activity, such as publishing their research and/or presenting their findings at national conventions.

  • Name: Karuna Rasineni 
  • Title: Assistant professor, UNMC Division of Gastroenterology and Hepatology, Department of Internal Medicine
  • Joined UNMC: 2010 
  • Hometown: Venkatadri Palli, Andhra Pradesh, India     

Research focus:   

  • Alcohol-associated fatty liver disease 
  • Non-alcoholic fatty liver disease 
  • Aging and its effects on alcohol-associated fatty liver disease 

Research goal: The goal of my work is to employ metabolism-centric approaches to gain a more complete understanding of metabolic hormone (ghrelin, insulin, liver expressed antimicrobial peptide-2 and adiponectin) mediated alterations in multiple pathways and organ-interactions (gut, pancreas, adipose and liver axis) to promote the development of fatty liver diseases. 

Why is research important in the world today? Hepatic steatosis, characterized by the accumulation of fat in the liver, is the earliest and most common pathology during the development of the two most common chronic liver diseases, alcohol-associated liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD). Both ALD and NAFLD are emerging public health issues globally. Nearly all patients with alcohol use disorder develop fatty liver. Additionally, about 100 million individuals in the United States are estimated to have non-alcoholic fatty liver which results from consuming a high fat/high sugar diet. Since fat accumulation is the "first hit" that leaves the liver more vulnerable to develop progressive liver injury, hepatic steatosis is a prime target for therapeutic intervention. Many times, liver transplantation is the only option available for treatment of patients with advanced liver disease. Therefore, studies that could lead to development of therapeutic strategies for treating fatty liver would be important and medically advantageous. 

My research will make a difference because: A better understanding of the role of hormone-mediated organ interaction in pathogenesis of fatty liver could help us to identify new therapeutic targets and strategies.   

The best advice I’ve ever received is: Let your work speak for you.  

Three things you may not know about me are:  

  • I come from a very large agricultural family in India with 14 first cousins. 
  • I like to listen to old Telegu melody songs. 
  • I like to visit a new pilgrimage city during annual trips to India.  

Ramesh babu Modupalli
January 28, 2022 at 1:35 AM

Happy to hear a girl from my village climbed such heights,god bless you dear

January 25, 2022 at 6:06 PM

Congratulations karuna

Madan Kumar
January 25, 2022 at 10:23 AM

Congratulations on your well-deserved success!

January 25, 2022 at 6:34 AM

You always pours 100% efforts. this gives immense boost for further studies. congratulations karuna : yogeshwarareddy

sreenivasulu Pathakamuri
January 24, 2022 at 9:43 PM

Congratulations Karuna

P Mohan Krishna
January 24, 2022 at 8:12 PM

Congratulations akka.

Murali Ganesan
January 24, 2022 at 6:09 PM

Congratulations Karuna.

Kusum K. Kharbanda
January 24, 2022 at 4:37 PM

Congratulations, Karuna!! It is a well-deserved honor. We are so proud of you!!

Chaithanya Mulakala
January 24, 2022 at 2:38 PM

Congratulations on your incredible success aka ! I'm incredibly happy for you. I saw you working and managing family so hard every day to achieve this and you deserve it .You set an amazing example for everyone in the family.

Jagadeesh N
January 24, 2022 at 1:02 PM

Congratulations, Akka.... Proud to see you honoured.

Rasineni Murali Krishna
January 24, 2022 at 11:44 AM

Heartfelt congratulations to you.

Todd Wyatt
January 24, 2022 at 10:08 AM

Well-deserved recognition! Your VA and alcohol research colleagues are proud of you!

Amy Dodson
January 24, 2022 at 7:50 AM

Congratulations Karuna!