Services & Available Mouse Models

The Core will provide humanized mouse models to the researchers at UNMC and also at other institutions around the nation, in the form of collaborations. A part (10%) of the R24 grant is dedicated to establish new collaborations and generate preliminary data for the new research projects involving humanized mice. A description of different humanized mouse models is listed below, and interested researchers are requested to contact the directors to further consult about the projects.

Available Mouse Models

1. NSG mice reconstituted with human CD34+ stem cells (umbilical cord blood) to generate functional human immune system. 
2. NSG mice reconstituted with human peripheral blood lymphocytes (PBL).  
3. TK-NOG mice reconstituted with human liver (human hepatocyte transplanted). 
4. TK-NOG mice transplanted with human CD34+ stem cells and human hepatocytes- dual reconstituted with human immune system and liver.

New Projects and Services

A part of the NIH R24 grant is dedicated to establish new collaborations and generate preliminary data for the new research projects involving humanized mice. Interested researchers are requested to submit the new project application briefly describing their idea and the core will provide up to 10-15 humanized mice to the investigator to generate preliminary data. The applications can be directly sent to ctmm@unmc.edu.

For any pilot projects or for grant applications involving humanized mice, contact us for free consultations to discuss and develop the experimental plan. We will also help with the budget and preparing the subcontract for grant application.